MAB386
Anti-Myelin Basic Protein Antibody
CHEMICON®, rat monoclonal, 12
Szinonimák:
MBP
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(4)
About This Item
UNSPSC kód:
12352203
eCl@ss:
32160702
NACRES:
NA.41
klón:
12, monoclonal
application:
ELISA
ICC
IHC
RIA
WB
ICC
IHC
RIA
WB
faj reaktivitás:
human, rat, sheep, mouse, rabbit, chicken, guinea pig, bovine, all
technika/technikák:
ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
radioimmunoassay: suitable
western blot: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
radioimmunoassay: suitable
western blot: suitable
citations:
314
Javasolt termékek
Terméknév
Anti-Myelin Basic Protein Antibody, a.a. 82-87, culture supernatant, clone 12, Chemicon®
biológiai forrás
rat
Minőségi szint
antitest forma
culture supernatant
antitest terméktípus
primary antibodies
klón
12, monoclonal
faj reaktivitás
human, rat, sheep, mouse, rabbit, chicken, guinea pig, bovine, all
gyártó/kereskedő neve
Chemicon®
technika/technikák
ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
radioimmunoassay: suitable
western blot: suitable
izotípus
IgG2a
NCBI elérési szám
UniProt elérési szám
kiszállítva
dry ice
célzott transzláció utáni módosítás
unmodified
Géninformáció
human ... MBP(4155)
mouse ... Mbp(17196)
rat ... Mbp(24547)
Általános leírás
The two major components of CNS myelin are Myelin Basic Protein (MBP) and proteolipid protein (PLP), occuring in roughly equimolar proportions. There are many neurological disorders associated with deficiencies of myelin assembly and structure. For example Multiple Sclerosis is a human disease due to multiple factors but generally characterized by the degradation of the myelin sheath. MBP ususally refers to the 18.5 kDa isoform, which is one of the most abundant proteins of the myelin sheath of adult human and bovine CNS. Genetically, MBP is the product of differential splicing of a single mRNA transcript. In humans there are 4 isoforms, 21.5, 20.2, 18.5, and 17.2 kDa. Thus, MBP are present in multiple isoforms, part of a large family of developmentally expressed, translocatable, and highly post-translationally modifed proteins with multiple binding partners. Structurally, MBP displays a predominately unorganized form with greater than 75% in random coil. Other non-CNS related functions of myelin include insulin induction and glucagon release from pancreatic islets.
Egyediség
Reacts with MBP from all species tested including human, bovine, sheep, rabbit, mouse, rat, guinea pig and chicken.
Reacts with MBP from all species tested. It reacts weakly with peptides ending in the phe 91 where the 91-92 phe-phe bond is broken. Synthetic peptide 82-99 reacts very well as does intact MBP. Mapped to the region DENPVV.
Immunogén
Bovine myelin basic protein
Epitope: a.a. 82-87
Alkalmazás
Anti-Myelin Basic Protein Antibody, a.a. 82-87 is an antibody against Myelin Basic Protein for use in ELISA, IC, IH, RIA & WB.
Immunohistochemistry:
A previous lot of this antibody was used on frozen sections.
ELISA/RIA:
1:1000 dilution of a previous lot of this antibody was used in ELISA/RIA.
Western Blotting:
Identifies an 18-20kDa band in westerns.
Optimal working dilutions must be determined by end user.
A previous lot of this antibody was used on frozen sections.
ELISA/RIA:
1:1000 dilution of a previous lot of this antibody was used in ELISA/RIA.
Western Blotting:
Identifies an 18-20kDa band in westerns.
Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neuronal & Glial Markers
Neurochemistry & Neurotrophins
Neuronal & Glial Markers
Neurochemistry & Neurotrophins
Minőség
Evaluated by Western Blot on Mouse brain lysates.
Western Blot Analysis:
1:500 dilution of antibody lot detected four isoforms of MBP on 10 µg of Mouse brain lysates.
Western Blot Analysis:
1:500 dilution of antibody lot detected four isoforms of MBP on 10 µg of Mouse brain lysates.
Cél megnevezése
18-20 kDa
Fizikai forma
Liquid containing 0.1% sodium azide.
Unpurified
Tárolás és stabilitás
Stable for 1 year at -20ºC from date of receipt.
Analízis megjegyzés
Control
Brain tissue
Brain tissue
Egyéb megjegyzések
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Jogi információk
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Nem találja a megfelelő terméket?
Próbálja ki a Termékválasztó eszköz. eszközt
javasolt
Tárolási osztály kódja
12 - Non Combustible Liquids
WGK
nwg
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
Már rendelkezik ezzel a termékkel?
Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.
Az ügyfelek ezeket is megtekintették
The novel BTB/POZ and zinc finger factor Zbtb45 is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells.
Sodersten, E; Lilja, T; Hermanson, O
Cell Cycle null
Xiao Ling Kuai et al.
Stem cell research & therapy, 6, 30-30 (2015-04-19)
Globoid cell leukodystrophy (GLD) is a severe disorder of the central and peripheral nervous system caused by the absence of galactocerebrosidase (GALC) activity. Cell-based therapies are highly promising strategies for GLD. In this study, G-Olig2 mouse embryonic stem cells (ESCs)
An ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of Ranvier.
Gasser, A; Ho, TS; Cheng, X; Chang, KJ; Waxman, SG; Rasband, MN; Dib-Hajj, SD
The Journal of Neuroscience null
Critical role for PAR1 in kallikrein 6-mediated oligodendrogliopathy.
Burda, JE; Radulovic, M; Yoon, H; Scarisbrick, IA
Glia null
Jane A English et al.
PloS one, 7(6), e39509-e39509 (2012-06-30)
Neuroproteomics is a powerful platform for targeted and hypothesis driven research, providing comprehensive insights into cellular and sub-cellular disease states, Gene × Environmental effects, and cellular response to medication effects in human, animal, and cell culture models. Analysis of sub-proteomes
Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.
Lépjen kapcsolatba a szaktanácsadással