764205

Alkyne-PEG4-maleimide

90% (HPLC)

• Szinonimák: Acetylene-PEG4-maleimide
• Tapasztalati képlet (Hill-képlet): C₁₈H₂₆N₂O₇
• Molekulatömeg: 382.41
• MDL-szám: MFCD22380740
• UNSPSC kód: 12352111
• PubChem Substance ID: 329767106
• NACRES: NA.22
• Forma: liquid
• Teszt: 90% (HPLC)

Tulajdonságok

• Minőségi szint: 100
• Teszt: 90% (HPLC)
• Forma: liquid
• reakcióalkalmasság: reaction type: click chemistry; reagent type: cross-linking reagent
• mp: 62-67 °C
• funkcionális csoport: alkyne; maleimide
• tárolási hőmérséklet: −20°C
• SMILES string: O=C(N1CCC(NCCOCCOCCOCCOCC#C)=O)C=CC1=O
• InChI: 1S/C18H26N2O7/c1-2-8-24-10-12-26-14-15-27-13-11-25-9-6-19-16(21)5-7-20-17(22)3-4-18(20)23/h1,3-4H,5-15H2,(H,19,21)
• Nemzetközi kémiai azonosító kulcs: GHEBECZRHJXPTL-UHFFFAOYSA-N

Leírás

Alkalmazás

Alkyne-PEG4-maleimide has been used for modification of Csy containing bacterial collagens by introducing alkyne moiety to enable it for further chemical modification.

Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a thiol. The maleimide group will react preferentially with thiols to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification cysteine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable