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Jones reagent

• Szinonimák: Jone′s reagent, Chromium trioxide solution in sulfuric acid, Sulfuric acid-chromium trioxide mixture
• CAS-szám: 65272-70-0
• MDL-szám: MFCD22199316
• UNSPSC kód: 12352000
• PubChem Substance ID: 329766706
• NACRES: NA.22

Tulajdonságok

• form: liquid
• Minőségi szint: 100
• összetétel: 2 M CrO₃ in aqueous H₂SO₄
• reakcióalkalmasság: core: chromium; reagent type: catalyst; reagent type: oxidant
• sűrűség: 1.298 g/mL at 25 °C
• SMILES string: O=[Cr](=O)=O.OS(O)(=O)=O
• InChI: 1S/Cr.H2O4S.3O/c;1-5(2,3)4;;;/h;(H2,1,2,3,4);;;
• Nemzetközi kémiai azonosító kulcs: HNPXHFOTGAXAJY-UHFFFAOYSA-N

Leírás

Általános leírás

• Jones reagent is a solution of chromium trioxide in aqueous sulfuric acid.
• Using acetone as a reaction solvent, the reagent is usually used for the oxidation of primary and secondary alcohols to carboxylic acids and ketones, respectively.
• The oxidation is very rapid and exothermic.
• The reagent tolerates a variety of functionalities, such as, for example, unsaturated bonds, which are rarely oxidized.

For a comprehensive review of chromium-based reagents, see "Oxidation of Alcohols to Aldehydes and Ketones" by Tojo and Fernández, Springer Berlin, 2006, 1-97.

Alkalmazás

Jones reagent can be used:

• In the oxidative cleavage of various alkenes into carboxylic acids and ketones using a catalytic amount of osmium tetroxide.
• To prepare symmetrical binaphthols by oxidative dehydrodimerization of substituted naphthols.
• To synthesize acyl-naphthols and substituted isocoumarins from 2-(4-hydroxy-but-1-ynyl)benzaldehydes.

Biztonsági adatok

• Piktogramok: GHS03,GHS06,GHS08,GHS05,GHS09
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H271,H290,H301,H312,H314,H317,H330,H334,H335,H340,H350,H361f,H372,H410
• Óvintézkedésre vonatkozó mondatok: P210 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Veszélyességi osztályok: Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Met. Corr. 1 - Muta. 1B - Ox. Liq. 1 - Repr. 2 - Resp. Sens. 1 - Skin Corr. 1A - Skin Sens. 1 - STOT RE 1 Inhalation - STOT SE 3
• Célzott szervek: Respiratory system
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable