902578

Hydroxy-PEG6-t-butyl ester

≥95%

• Synonim(y): tert-Butyl 1-hydroxy-3,6,9,12,15,18-hexaoxahenicosan-21-oate, HO-PEG6-CO-OtBu
• Wzór empiryczny (zapis Hilla): C₁₉H₃₈O₉
• Numer CAS: 361189-64-2
• Masa cząsteczkowa: 410.50
• Kod UNSPSC: 51171641
• NACRES: NA.22

Właściwości

• Próba: ≥95%
• Postać: liquid
• przydatność reakcji: reagent type: cross-linking reagent
• współczynnik refrakcji: n/D 1.454
• gęstość: 1.068
• grupa funkcyjna: ester; hydroxyl
• temp. przechowywania: −20°C
• ciąg SMILES: O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCO
• InChI: 1S/C19H38O9/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h20H,4-17H2,1-3H3
• Klucz InChI: VGGDPFAYSOSIOK-UHFFFAOYSA-N

Opis

Zastosowanie

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or roteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Inne uwagi

Synthesis and Molecular Recognition Studies of the HNK-1 Trisaccharide and Related Oligosaccharides. The Specificity of Monoclonal Anti-HNK-1 Antibodies as Assessed by Surface Plasmon Resonance and STD NMR

Maleimide-oligo(ethylene glycol) Derivatives of Camptothecin as Albumin-Binding Prodrugs: Synthesis and Antitumor Efficacy

Informacje prawne

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable