Pramipexole dihydrochloride (A1237) is described with the synonym (S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride, indicating it is the S (L) enantiomer. The optical rotation is measured and can be found in the Certificate of Analysis (COA) for this product. The specification for this product is between -60° and -70°, which is consistent with the S (L) enantiomer of pramipexole.
A1237
普拉克索 二盐酸盐
>98% (HPLC), Dopamine D2 and D3 receptor agonist, powder
别名:
(S)-2-氨基-4,5,6,7-四氢-6-（丙氨基）苯并噻唑 二盐酸盐, PPX 二盐酸盐
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关于此项目
经验公式（希尔记法）:
C10H17N3S · 2HCl
化学文摘社编号:
分子量:
284.25
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
价格与库存信息目前不能提供
产品名称
普拉克索 二盐酸盐, >98% (HPLC), powder
Quality Level
assay
>98% (HPLC)
form
powder
storage condition
desiccated
color
white to off-white
solubility
H2O: >20 mg/mL
originator
Boehringer Ingelheim
storage temp.
2-8°C
SMILES string
Cl.Cl.CCCN[C@H]1CCc2nc(N)sc2C1
InChI
1S/C10H17N3S.2ClH/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H/t7-;;/m0../s1
InChI key
QMNWXHSYPXQFSK-KLXURFKVSA-N
Gene Information
human ... DRD2(1813), DRD3(1814), DRD4(1815)
General description
普拉克索属于非麦角碱类，来源于苯并噻唑。与其他麦角碱衍生物药物相比，对 D2 和 D3 受体（多巴胺受体）有较强的亲和力。但是，它不与非多巴胺受体相关，例如肾上腺素能受体和 5-羟色胺受体。
Application
盐酸普拉克索已被用作多巴胺（DA）耗尽的纹状体切片中的D2受体激动剂。[3]
Biochem/physiol Actions
普拉克索是一种多巴胺激动剂，对 D3 和 D2 受体亚型具有活性。研究发现普拉克索具有独立于其多巴胺受体激动作用的神经保护作用。减少线粒体活性氧 (ROS) 产生，抑制凋亡途径的激活。
普拉克索是帕金森病和不安腿综合征的治疗药物。在 MDD（重度抑郁症）和双相抑郁患者中也表现出抗抑郁疗效。[6]
盐酸普拉克索一水合物是一种多巴胺激动剂，对 D3 和 D2 受体亚型具有活性。
Features and Benefits
该化合物由 Boehringer Ingelheim 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。
这种化合物是 ADME 毒性研究的特色产品。点击此处发现更多特色 ADME 毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
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此商品 | |||
|---|---|---|---|
| assay >98% (HPLC) | assay - | assay - | assay ≥98% (HPLC) |
| form powder | form - | form powder | form powder |
| Quality Level 100 | Quality Level 300 | Quality Level 200 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-30°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility H2O: >20 mg/mL | solubility - | solubility alcohol: 20 mg/mL, H2O: soluble | solubility H2O: 20 mg/mL, clear |
| storage condition desiccated | storage condition - | storage condition - | storage condition desiccated |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - STOT SE 3
target_organs
Central nervous system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Haritz Jiménez-Urbieta et al.
Neurobiology of aging, 75, 126-135 (2018-12-21)
Treatment with dopaminergic agonists such as pramipexole (PPX) contributes to the development of impulse control disorders (ICDs) in patients with Parkinson's disease (PD). As such, animal models of abnormal impulse control in PD are needed to better study the pathophysiology
Jose A Franco-Chaves et al.
Journal of affective disorders, 149(1-3), 319-325 (2013-03-23)
Antidepressants that act on two or more amine neurotransmitters may confer higher remission rates when first-line agents affecting a single neurotransmitter have failed. Pramipexole, a dopamine agonist, has antidepressant effects in patients with major depressive disorder (MDD). This pilot study
Serdar Tort et al.
International journal of pharmaceutics, 579, 119164-119164 (2020-02-23)
Floating gastro-retentive delivery systems can prolong the gastric residence providing sustained drug release. In this study, we report on self-inflating effervescence-based electrospun nanofiber membranes embedding polyethylene oxide/sodium bicarbonate cast films. In this system, sodium bicarbonate results in an effervescence effect
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A1237-10MG | 04061835257751 |
| A1237-50MG | 04061835257768 |
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Is this pramipexole the pure L enantiomer? Or a racemic mixture of L and R? If pure enantiomer: 1. how was this determined and 2. are the data supporting this available?
1 answer-
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