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SML1644

Sigma-Aldrich

MRT68921 二盐酸盐

≥98% (HPLC)

别名:

N- [3-[[5-环丙基-2-[（1,2,3,4-四氢-2-甲基-6-异喹啉基）氨基] -4-嘧啶基]氨基]丙基]-环丁烷甲酰胺 二盐酸盐

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About This Item

经验公式（希尔记法）:
C25H34N6O · 2HCl
CAS号:
1190379-70-4
分子量:
507.50
分類程式碼代碼:
12352200
PubChem物質ID:
329825985
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

H2O: 20 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

CN(C1)CCC2=C1C=CC(NC3=NC=C(C4CC4)C(NCCCNC(C5CCC5)=O)=N3)=C2.[H]Cl.[H]Cl

InChI

1S/C25H34N6O.2ClH/c1-31-13-10-19-14-21(9-8-20(19)16-31)29-25-28-15-22(17-6-7-17)23(30-25)26-11-3-12-27-24(32)18-4-2-5-18;;/h8-9,14-15,17-18H,2-7,10-13,16H2,1H3,(H,27,32)(H2,26,28,29,30);2*1H

InChI 密鑰

NLKPLTWKINJHCK-UHFFFAOYSA-N

應用

MRT68921二盐酸盐的应用：
  • 作为SH-SY5Y神经母细胞瘤细胞中Unc-51样激酶1(ULK1)的抑制剂
  • 作为肝内淋巴细胞中ULK1和ULK2激酶的抑制剂
  • 检测其作为ULK1抑制剂，对泛素特异性肽酶24(USP24)敲低人神经胶质瘤H4细胞中自噬体积聚的缓解作用

生化／生理作用

MRT68921 是体外 ULK1 和 ULK2 激酶的细胞渗透的、高效和特异性抑制剂，可降低细胞中 ULK1 的活性并阻止自噬诱导。MRT68921 阻断 mTOR 依赖性自噬。
MRT68921具有细胞毒性，通过作用于氧化应激信号而杀死癌细胞，是一种有效的肿瘤治疗药物。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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