D5919

Diacylglycerol Kinase Inhibitor I

solid

• Synonym(s): 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidin­yl]ethyl]-7-methyl-5H-thiazolo-[3,2-a]-pyrimidin-5-one, R59022
• Empirical Formula (Hill Notation): C₂₇H₂₆FN₃OS
• CAS Number: 93076-89-2
• Molecular Weight: 459.58
• NACRES: NA.77
• PubChem Substance ID: 24893986
• UNSPSC Code: 41106300
• MDL number: MFCD00055114
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: solid
• color: pale yellow
• solubility: 0.1 M HCl: slightly soluble, 0.1 M NaOH: slightly soluble, DMSO: soluble, H₂O: insoluble, ethanol: soluble, ethyl acetate: soluble
• storage temp.: −20°C
• SMILES string: CC1=C(CCN2CCC(\CC2)=C(\c3ccccc3)c4ccc(F)cc4)C(=O)N5C=CSC5=N1
• InChI: 1S/C27H26FN3OS/c1-19-24(26(32)31-17-18-33-27(31)29-19)13-16-30-14-11-22(12-15-30)25(20-5-3-2-4-6-20)21-7-9-23(28)10-8-21/h2-10,17-18H,11-16H2,1H3
• InChI key: MFVJXLPANKSLLD-UHFFFAOYSA-N

Description

General description

Diacylglycerol Kinase Inhibitor I prevents the formation of foreign body giant cell (FBGC).[1] It inhibits the phosphorylation of diacylglycerol to phosphatidic acid. Diacylglycerol Kinase Inhibitor I functions as a serotonin (5-HT) receptor (5-HTR) antagonist.[2] It stimulates apoptosis and autophagy in neuronal cell line NG108-15.[3]

Application

Diacylglycerol Kinase Inhibitor I has been used as an inhibitor to study suppression of T cell function using advanced generation human CAR (chimeric antigen receptors) T cells.

Biochem/physiol Actions

Diacylglycerol kinase inhibitor. Inhibits formation of [³⁸P]1-Oleoxyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC₅₀ = 3.3 μM.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)