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Acamprosate calcium

Name: Acamprosate calcium
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

3-(Acetylamino)-1-propanesulfonic acid calcium salt (2:1)

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About This Item

Empirical Formula (Hill Notation):

C₅H₁₀Ca_0.5NO₄S

CAS Number:

77337-73-6

Molecular Weight:

200.24

MDL number:

MFCD00886588

UNSPSC Code:

12352200

PubChem Substance ID:

329770909

EC Number:

278-665-3

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

powder

solubility

H₂O: >5 mg/mL

storage temp.

room temp

SMILES string

CC(=O)NCCCS(=O)(=O)O[Ca]OS(=O)(=O)CCCNC(C)=O

InChI

1S/2C5H11NO4S.Ca/c2*1-5(7)6-3-2-4-11(8,9)10;/h2*2-4H2,1H3,(H,6,7)(H,8,9,10);/q;;+2/p-2

InChI key

BUVGWDNTAWHSKI-UHFFFAOYSA-L

Gene Information

Description

Biochem/physiol Actions

Acamprosate calcium is a GABA γ-aminobutyric acid agonist.

Acamprosate calcium is a synthetic analog of γ-aminobutyric acid (GABA) and a GABAB receptor agonist.[1] Acamprosate calcium has been used in alcohol dependence treatments[2] and may be an effective augmentation therapy anxiety patients.[3]

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Show Differences

1 of 1

This Item	1000554	SML0488	SML0234
Sigma-Aldrich A6981 Acamprosate calcium	USP 1000554 Acamprosate calcium	Sigma-Aldrich SML0488 Dobesilate Calcium	Sigma-Aldrich SML0234 Mitiglinide calcium
form powder	form -	form powder	form powder
assay ≥98% (HPLC)	assay -	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 100
storage temp. room temp	storage temp. 2-8°C	storage temp. room temp	storage temp. room temp
solubility H₂O: >5 mg/mL	solubility -	solubility H₂O: 15 mg/mL, clear	solubility DMSO: ≥10 mg/mL at warmed to 60 °C
Gene Information human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444)	Gene Information human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444)	Gene Information -	Gene Information -

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000421018

0000362261

052M4709V

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Pharmacokinetics of acamprosate calcium in healthy Chinese subjects after oral administration of three dosage levels.

Fan Xu et al.

Arzneimittel-Forschung, 59(12), 631-634 (2010-01-30)

To study the pharmacokinetics of acamprosate calcium (CAS 77337-73-6) in healthy Chinese subjects after oral administration of three dosage levels, 12 healthy subjects were divided into three groups and given a single oral dose of 333 or 666 or 1332

Open-label trial of acamprosate as a treatment for anxiety.

Marc Hertzman et al.

Primary care companion to the Journal of clinical psychiatry, 11(5), 267-267 (2009-12-04)

Acamprosate. A review of its pharmacology and clinical potential in the management of alcohol dependence after detoxification.

M I Wilde et al.

Drugs, 53(6), 1038-1053 (1997-06-01)

Acamprosate (calcium acetylhomotaurinate), a synthetic compound with a similar chemical structure to that of gamma-aminobutyric acid, is thought to act via several mechanisms affecting multiple neurotransmitter systems; inhibition of neuronal hyperexcitability by antagonism of excitatory amino acid activity and reduction

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Global Trade Item Number

SKU	GTIN
A6981-10MG	04061832071510
A6981-50MG	04061832071527

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