Ugrás a tartalomra
Merck

1008501

USP

Acetylcholine chloride

United States Pharmacopeia (USP) Reference Standard

Szinonimák:

ACh

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

Lineáris képlet:
(CH3)3N+CH2CH2OCOCH3Cl-
CAS-szám:
Molekulatömeg:
181.66
Beilstein:
3571875
MDL-szám:
UNSPSC kód:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API-család

acetylcholine

gyártó/kereskedő neve

USP

mp

146-150 °C (lit.)

alkalmazás(ok)

pharmaceutical (small molecule)

format

neat

tárolási hőmérséklet

2-8°C

SMILES string

[Cl-].CC(=O)OCC[N+](C)(C)C

InChI

1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1

Nemzetközi kémiai azonosító kulcs

JUGOREOARAHOCO-UHFFFAOYSA-M

Géninformáció

human ... CHRM3(1131)

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Általános leírás

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Alkalmazás

Acetylcholine chloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:
  • Acetylcholine Chloride for Ophthalmic Solution
  • Methacholine Chloride

Biokémiai/fiziológiai hatások

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Analízis megjegyzés

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Egyéb megjegyzések

Sales restrictions may apply.

kapcsolódó termék

Product No.
Leírás
Árazás

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 2

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable


Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

Már rendelkezik ezzel a termékkel?

Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Sulan Luo et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(4), 1842-1853 (2014-01-09)
This study was performed to discover and characterize the first potent α3β2-subtype-selective nicotinic acetylcholine receptor (nAChR) ligand. A novel α4/7-conotoxin, α-CTxLvIA, was cloned from Conus lividus. Its pharmacological profile at Xenopus laevis oocyte-expressed rat nAChR subtypes was determined by 2-electrode
A Altomare et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(1), G77-G88 (2014-05-17)
It has been shown, in animal models, that gastrointestinal tract (GIT) motility is influenced by temperature; nevertheless, the basic mechanism governing thermal GIT smooth muscle responses has not been fully investigated. Studies based on physiologically tuned mathematical models have predicted
Peter Ong et al.
Circulation, 129(17), 1723-1730 (2014-02-28)
Coronary spasm can cause myocardial ischemia and angina in patients with and those without obstructive coronary artery disease. However, provocation tests using intracoronary acetylcholine administration are rarely performed in clinical routine in the United States and Europe. Thus, we assessed
Eliane Proulx et al.
Cellular and molecular life sciences : CMLS, 71(7), 1225-1244 (2013-10-15)
Cholinergic modulation of prefrontal cortex is essential for attention. In essence, it focuses the mind on relevant, transient stimuli in support of goal-directed behavior. The excitation of prefrontal layer VI neurons through nicotinic acetylcholine receptors optimizes local and top-down control
Xiaoqun Zhang et al.
Journal of neurochemistry, 129(4), 581-590 (2014-01-31)
The GluN2 subunits that compose NMDA receptors (NMDARs) determine functional and pharmacological properties of the receptor. In the striatum, functions and potential dysfunctions of NMDARs attributed to specific GluN2 subunits have not been clearly elucidated, although NMDARs play critical roles

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