SRP3090
IL-3 human
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Szinonimák:
HCGF, MCGF (Mast cell growth factor), Multi-CSF, P-cell stimulation factor
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
UNSPSC kód:
12352202
NACRES:
NA.32
Javasolt termékek
biológiai forrás
human
rekombináns
expressed in E. coli
Teszt
≥98% (HPLC)
≥98% (SDS-PAGE)
Forma
lyophilized
hatékonyság
≤0.1 ng/mL ED50
molekulatömeg
15.0 kDa
kiszerelés
pkg of 10 μg
technika/technikák
cell culture | mammalian: suitable
szennyeződések
<0.1 EU/μg endotoxin, tested
szín
white to off-white
UniProt elérési szám
kiszállítva
wet ice
tárolási hőmérséklet
−20°C
Géninformáció
human ... IL3(3562)
Általános leírás
IL3 (interleukin 3) is a haematopoietic growth factor, the gene for which is localized to human chromosome locus 5.
Recombinant human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues.
Recombinant human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues.
Biokémiai/fiziológiai hatások
IL3 (interleukin 3) promotes the survival, proliferation and differentiation of haematopoietic progenitor cells. It also functions as an activator of basophils thus, resulting in significant increase in antigen and IgE-mediated release of cytokines and other mediators. Certain variants in this gene confer protection against malaria attack, and thus, this gene might play a role in the pathophysiology of falciparum malaria. SNP (single nucleotide polymorphism) rs40401 in this gene and smoking have a positive correlation with asthma in Japanese women. IL3 is involved in brain development and has a direct influence on the proliferation and survival of neural progenitor cell population, thereby also controlling human brain volume.
Szekvencia
APMTQTTSLK TSWVNCSNMI DEIITHLKQP PLPLLDFNNL NGEDQDILME NNLRRPNLEA FNRAVKSLQN ASAIESILKN LLPCLPLATA APTRHPIHIK DGDWNEFRRK LTFYLKTLEN AQAQQTTLSL AIF
Fizikai forma
Lyophilized with no additives.
Feloldás
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20°C to -80°C.
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Analitikai tanúsítványok (COA)
Lot/Batch Number
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Az ügyfelek ezeket is megtekintették
Y Miyake et al.
Scandinavian journal of immunology, 79(6), 410-414 (2014-04-02)
Three previous genetic association studies conducted in Korea and China investigated the relationship between IL3 single nucleotide polymorphism (SNP) rs40401 and asthma, but their results were inconsistent. We examined this relationship and the possibility of an interaction between IL3 SNP
Christian G Meyer et al.
Human molecular genetics, 20(6), 1173-1181 (2011-01-13)
Using segregation analyses, control of malaria parasites has previously been linked to a major gene within the chromosomal region 5q31-33, but also to complex genetic factors in which effects are under substantial age-dependent influence. However, the responsible gene variants have
Xiong-jian Luo et al.
PloS one, 7(11), e50375-e50375 (2012-12-12)
One of the most significant evolutionary changes underlying the highly developed cognitive abilities of humans is the greatly enlarged brain volume. In addition to being far greater than in most other species, the volume of the human brain exhibits extensive
J N Ihle
Chemical immunology, 51, 65-106 (1992-01-01)
Considerable information has accumulated over the past several years relating to the biological activities of IL-3 which supports that concept that IL-3 has a unique capacity to support the proliferation and differentiation of a wide spectrum of hematopoietic cells. The
S Yousefi et al.
Allergy, 70(9), 1184-1188 (2015-06-05)
Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report
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