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S8626

Sigma-Aldrich

Sulfadiazine

99.0-101.0%

Szinonimák:

4-Amino-N-(2-pyrimidinyl)benzenesulfonamide, N1-(Pyrimidin-2-yl)sulfanilamide

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About This Item

Tapasztalati képlet (Hill-képlet):
C10H10N4O2S
CAS-szám:
68-35-9
Molekulatömeg:
250.28
Beilstein:
6733588
EC-szám:
200-685-8
MDL-szám:
MFCD00006065
UNSPSC kód:
51283908
PubChem Substance ID:
24899802
NACRES:
NA.85

leírás

Solubility - Practically insoluble in water, slightly soluble in acetone, very slightly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and in dilute mineral acids.

Minőségi szint

200

Teszt

99.0-101.0%

form

powder or crystals

szín

white to faint yellow, faint pink

mp

253 °C (dec.) (lit.)

oldhatóság

96% ethanol: very slightly soluble
acetone: slightly soluble
water: practically insoluble

antibiotikus hatásspektrum

Gram-negative bacteria
Gram-positive bacteria
mycoplasma

Hatásmechanizmus

DNA synthesis | interferes
enzyme | inhibits

SMILES string

Nc1ccc(cc1)S(=O)(=O)Nc2ncccn2

InChI

1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)

Nemzetközi kémiai azonosító kulcs

SEEPANYCNGTZFQ-UHFFFAOYSA-N

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Általános leírás

Chemical structure: sulfonamide

Alkalmazás

Sulfadiazine is a short-acting sulfonamide that is commonly used with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome. It is also used to treat newborns with congenital infections. Sulfadiazine has been used to control acute infections when studying murine models of reactivated toxoplasmosis.

Biokémiai/fiziológiai hatások

Sulfadiazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Egyéb megjegyzések

Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids

Figyelmeztetés

Warning

Figyelmeztető mondatok

H302,H361d,H411

Óvintézkedésre vonatkozó mondatok

P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313

Veszélyességi osztályok

Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 2

Egyéni védőeszköz

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Sulfadiazine-(phenyl-13C6) VETRANAL®, analytical standard

Supelco

32518

Sulfadiazine-(phenyl-13C6)

Sulfadiazine certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

73901

Sulfadiazine

Sulfapyridine ≥99.0%

Supelco

S6252

Sulfapyridine

Sulfadimethoxine 98.0-102.0%

Supelco

S7007

Sulfadimethoxine

Sulfathiazole

Supelco

S9876

Sulfathiazole

Sulfameter

Sigma-Aldrich

S0383

Sulfameter

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Spreading manure containing antibiotics in agriculture is assumed to stimulate the dissemination of antibiotic resistance in soil bacterial populations. Plant roots influencing the soil environment and its microflora by exudation of growth substrates might considerably increase this effect. In this
Ildiko R Dunay et al.
Antimicrobial agents and chemotherapy, 53(10), 4450-4456 (2009-07-29)
Immunocompromised patients are at risk of developing toxoplasmosis, and although chemotherapy is available, standard treatments are often complicated by severe side effects. Artemisinin is a new highly potent antimalarial drug that has activity against Toxoplasma gondii in vitro. However, artemisinin
Tamim M Niazi et al.
International journal of radiation oncology, biology, physics, 84(3), e305-e310 (2012-06-02)
For patients with anal canal and advanced rectal cancer, chemoradiation therapy is a curative modality or an important adjunct to surgery. Nearly all patients treated with chemoradiation experience some degree of radiation-induced dermatitis (RID). Prevention and effective treatment of RID
Pascale Meneceur et al.
Antimicrobial agents and chemotherapy, 52(4), 1269-1277 (2008-01-24)
Sulfadiazine, pyrimethamine, and atovaquone are widely used for the treatment of severe toxoplasmosis. Their in vitro activities have been almost exclusively demonstrated on laboratory strains belonging to genotype I. We determined the in vitro activities of these drugs against 17
Romain Sonneville et al.
Neurology, 79(17), 1762-1766 (2012-10-12)
Cerebral toxoplasmosis remains a common neurologic complication in patients with AIDS. In this study, we aimed to characterize the prognosis of patients with HIV infection with severe forms of cerebral toxoplasmosis and to investigate the effects of adjunctive steroids on
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