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S6256

Sigma-Aldrich

Sulfamethazine

99.0-101.0% (on dried basis)

Szinonimák:

4,6-Dimethylsulfadiazine, 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide, Sulfadimethyldiazine, Sulfadimidine

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)

About This Item

Tapasztalati képlet (Hill-képlet):
C12H14N4O2S
CAS-szám:
57-68-1
Molekulatömeg:
278.33
Beilstein:
261304
EC-szám:
200-346-4
MDL-szám:
MFCD00006066
UNSPSC kód:
51284910
PubChem Substance ID:
24899686
NACRES:
NA.85

Minőségi szint

200

Teszt

99.0-101.0% (on dried basis)

Forma

powder or crystals

tárolási körülmény

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

szín

white to off-white

antibiotikus hatásspektrum

Gram-negative bacteria
Gram-positive bacteria

Hatásmechanizmus

DNA synthesis | interferes
enzyme | inhibits

tárolási hőmérséklet

2-8°C

SMILES string

Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1

InChI

1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)

Nemzetközi kémiai azonosító kulcs

ASWVTGNCAZCNNR-UHFFFAOYSA-N

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Általános leírás

Chemical structure: sulfonamide

Alkalmazás

Sulfamethazine is an antibiotic used to treat bronchitis, prostatitis and urinary tract infections. It is used in disposition and depletion kinetic studies. It is used to develop detection techniques for quantification in fluids such as cows′ milk, honey and swine urine.

Biokémiai/fiziológiai hatások

Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.
An antimicrobial sulfur drug. Induces CYP3A4 expression and acetylated by N-acetyltransferase. Exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11.

Kiszerelés

25G,100G

Egyéb megjegyzések

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 2

Egyéni védőeszköz

Eyeshields, Gloves, type N95 (US)

Válasszon a legfrissebb verziók közül:

Analitikai tanúsítványok (COA)

Lot/Batch Number
0000410520
0000410520
0000401241
0000375918
0000401241

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Sulfaguanidine

Sigma-Aldrich

S8751

Sulfaguanidine

Sulfamethizole analytical standard, ≥99% (HPLC)

Supelco

S5632

Sulfamethizole

Sulfadimethoxine 98.0-102.0%

Supelco

S7007

Sulfadimethoxine

Sulfamethizole VETRANAL®, analytical standard

Supelco

46842

Sulfamethizole

Sulfamethoxypyridazine VETRANAL®, analytical standard

Supelco

46858

Sulfamethoxypyridazine

A D Mitchell et al.
Drug metabolism and disposition: the biological fate of chemicals, 14(2), 161-165 (1986-03-01)
Swine weighing 60-70 kg were orally administered 14C-sulfamethazine [4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzene[U-14C]sulfonamide] at 12-hr intervals for 7 days (165 mg/dose; 0.126-5.04 mCi/mmol). The animals were sacrificed at 8 hr or 2, 5, or 10 days after the last dose was given and tissues
C J Chapron et al.
Journal of clinical pharmacology, 16(7), 338-344 (1976-07-01)
The relationship between sulfamethazine disposition kinetics and acetylation phenotype was studied in man. Sulfamethazine pharmacokinetic parameters were determined after the administration of the drug as an oral suspension. When the half-life, acetylation rate constant, or per cent available dose excreted
Tangbin Yang et al.
Hybridoma (2005), 29(5), 403-407 (2010-11-06)
A specific monoclonal antibody (MAb) against sulfamethazine was produced with hybridoma technology. This assay shows very high sensitivity with IC50 of 0.4 ng/mL and LOD of 0.05 ng/mL when it was run in 0.02 mol/L PBS (pH 7.5). This MAb has shown high
M Rérat et al.
Preventive veterinary medicine, 103(4), 265-273 (2011-09-29)
The present study was conducted to evaluate the efficacy of two prophylactic antibiotic treatments against bovine respiratory disease (BRD) in veal calves. In addition, the antibiotic susceptibilities of isolated Pasteurellaceae were tested. The calves were treated either on the day
Vincent Curtin et al.
Molecular pharmaceutics, 10(1), 386-396 (2012-11-29)
The coprocessing of active pharmaceutical ingredient (API) with an excipient which has a high glass transition temperature (T(g)) is a recognized strategy to stabilize the amorphous form of a drug. This work investigates whether coprocessing a model API, sulfadimidine (SDM)
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