R0395

Rapamycin

from Streptomyces hygroscopicus, ≥95% (HPLC), powder, mTOR inhibitor

• Szinonimák: 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, AY 22989, Sirolimus
• Tapasztalati képlet (Hill-képlet): C₅₁H₇₉NO₁₃
• CAS-szám: 53123-88-9
• Molekulatömeg: 914.17
• MDL-szám: MFCD00867594
• UNSPSC kód: 12352200
• PubChem Substance ID: 57654583
• NACRES: NA.77

Tulajdonságok

• product name: Rapamycin from Streptomyces hygroscopicus, ≥95% (HPLC), powder
• Minőségi szint: 300
• Teszt: ≥95% (HPLC)
• form: powder
• szín: off-white
• oldhatóság: ethanol: 2 mM; DMSO: soluble
• antibiotikus hatásspektrum: fungi; yeast
• Hatásmechanizmus: enzyme | inhibits; protein synthesis | interferes
• tárolási hőmérséklet: −20°C
• SMILES string: CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC
• InChI: 1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
• Nemzetközi kémiai azonosító kulcs: QFJCIRLUMZQUOT-HPLJOQBZSA-N
• Géninformáció: human ... FKBP1A(2280)

Leírás

Általános leírás

Chemical structure: macrolide

Rapamycin is derived from Streptomyces hygroscopicus . It can inhibit viral replication. This natural anti-fungal antibiotic is a proven anti-aging agent. Rapamycin significantly inhibits mTORC1 regardless of age. It suppresses protein kinase C activity and enhances ion transport in A6 cells. It also suppresses the immune response in membrane and cytosolic preparations. Additionally, it has specific effects on the translation of endogenous mRNAs and inhibits the translation of 5′TOP mRNAs by blocking p70s6k activation in the signaling pathway. Rapamycin exhibits antineoplastic properties.

Alkalmazás

Rapamycin from Streptomyces hygroscopicus has been used:

•  to treat BV2 cells or BV2-LC3 cells for autophagy assay
• as an autophagy activator in the bone marrow mesenchymal stem cells (BM-MSCs) transfected with lentivirus carrier of small interfering RNA for FOXO3 (siFOXO3) to study the effects of Forkhead Box O3 (FOXO3) on the autophagy of BM-MSCs
• to pre-incubate villi to inhibit the mammalian target of rapamycin complex 1 (mTORC1) signaling

Biokémiai/fiziológiai hatások

A macrocyclic triene antibiotic that binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has anticancer activity.

Tulajdonságok és előnyök

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Egyéb megjegyzések

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

Biztonsági adatok

• Piktogramok: GHS08
• Figyelmeztetés: Warning
• Figyelmeztető mondatok: H351,H361fd
• Óvintézkedésre vonatkozó mondatok: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Veszélyességi osztályok: Carc. 2 - Repr. 2
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 2
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)