M0896

MPTP Hydrochloride

≥98% (AgNO3), powder, dopaminergic neurotoxin

• Szinonimák: MPTP HCl, Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride, MPTP hydrochloride
• Tapasztalati képlet (Hill-képlet): C₁₂H₁₅N · HCl
• CAS-szám: 23007-85-4
• Molekulatömeg: 209.72
• Beilstein: 3707312
• MDL-szám: MFCD00012790
• UNSPSC kód: 12352200
• PubChem Substance ID: 24896578
• NACRES: NA.77

Tulajdonságok

• product name: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride, powder
• form: powder
• Minőségi szint: 200
• drug control: kontrollierte Droge in Deutschland
• szín: white to off-white
• SMILES string: Cl[H].CN1CCC(=CC1)c2ccccc2
• InChI: 1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
• Nemzetközi kémiai azonosító kulcs: KOWJANGMTAZWDT-UHFFFAOYSA-N

Leírás

Általános leírás

MPTP shows its effects by causing inflammation, excitotoxicity, mitochondrial apoptosis, formation of inclusion bodies, and oxidative stress that leads to dopaminergic neuronal damage in the striatum and substantia nigra. In dopaminergic neurons, MPTP blocks the mitochondrial complex I which leads to mitochondrial dysfunction.

Alkalmazás

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride has been used to induce Parkinson′s disease (PD) in animal models:

• to study the effect of docosahexaenoic acid on the apelin distribution of the nervous system
• to study the behavioral impairments correlated to neurochemical deficits
• to study the effects of treadmill exercise on neuroprotection and neuroinflammation

MPTP has been used to study its effects on microglial innate immune memory. It has also been used to study the protective effects of phenylpropionamides in Pakinson’s diseased mice models.

Biokémiai/fiziológiai hatások

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a piperidine derivative and dopaminergic neurotoxin, useful in neurological research. MPTP is metabolized to 1-methyl-4-phenylpyridine (MPP+), which in turn can cause free radical production in vivo and lead to oxidative stress. Thus MPP+ is generally acknowledged as the active metabolite of MPTP. MPTP is widely used in in vivo research studies as a model for Parkinsonism. A review describes the application of MPTP in studies related to programmed cell death in neurogenerative diseases.

Dopaminergic neurotoxin.

Figyelmeztetés

Reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

Egyéb megjegyzések

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Biztonsági adatok

• Piktogramok: GHS06,GHS08
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H301,H370
• Óvintézkedésre vonatkozó mondatok: P260 - P264 - P270 - P301 + P310 - P405 - P501
• Veszélyességi osztályok: Acute Tox. 3 Oral - STOT SE 1
• Célzott szervek: Nervous system
• Tárolási osztály kódja: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3