F7876

Folic acid

≥97%

• Szinonimák: PteGlu, Pteroyl-L-glutamic acid, Vitamin M
• Tapasztalati képlet (Hill-képlet): C₁₉H₁₉N₇O₆
• CAS-szám: 59-30-3
• Molekulatömeg: 441.40
• Beilstein: 100781
• EC-szám: 200-419-0
• MDL-szám: MFCD00079305
• UNSPSC kód: 12352106
• eCl@ss: 34058014
• PubChem Substance ID: 57654192
• NACRES: NA.79

Tulajdonságok

• biológiai forrás: synthetic (organic)
• Minőségi szint: 200
• Teszt: ≥97%
• Forma: powder
• technika/technikák: HPLC: suitable
• szín: faint orange to dark orange-yellow; faint yellow to dark yellow
• mp: >285 °C
• tárolási hőmérséklet: room temp
• SMILES string: NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O
• InChI: 1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
• Nemzetközi kémiai azonosító kulcs: OVBPIULPVIDEAO-LBPRGKRZSA-N

Leírás

Alkalmazás

Folic acid has been used:

• to induce acute kidney injury in mice
• as a supplement to cultivate MCF-7 breast cancer cells.
• to construct folate or TNF-related apoptosis-including ligand (TRAIL)-conjugated nanomicelles

Biokémiai/fiziológiai hatások

Enzyme cofactor essential for the synthesis, methylation, and repair of DNA. Folic acid supplements may reduce colorectal cancer risk.

Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)