Összes fotó(2)
Fontos dokumentumok
E2645
Epidermal Growth Factor Receptor human
lyophilized powder, ≥15,000 units/mg protein (Bradford)
Szinonimák:
ERBB, ErbB1, HER1, EGFR
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)
About This Item
Javasolt termékek
biológiai forrás
human
Minőségi szint
Forma
lyophilized powder
hatékonyság
>15000.00 units/mg
specifikus aktivitás
≥15,000 units/mg protein (Bradford)
molekulatömeg
~170 kDa
kiszerelés
pkg of 500UN
tárolási körülmény
avoid repeated freeze/thaw cycles
technika/technikák
cell based assay: suitable
szín
white
oldhatóság
glycerol: 10%, clear to slightly hazy, colorless
UniProt elérési szám
kiszállítva
dry ice
tárolási hőmérséklet
−20°C
Géninformáció
human ... EGFR(1956)
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Általános leírás
Research area: Cell signaling
Epidermal growth factor receptor (EGFR) belongs to a family of cell surface receptors called receptor tyrosine kinases (RTKs) and is also the most studied member of this family. The EGFR is encoded by the ErbB gene, mapped to chromosome 7 q22. These receptors are attached to the cytoplasmic membrane and consist of an ectodomain (ECD), comprising of four subdomains called DI-DIV, a hydrophobic transmembrane domain, and an intracytoplasmic tyrosine kinase domain.
Epidermal growth factor receptor (EGFR) belongs to a family of cell surface receptors called receptor tyrosine kinases (RTKs) and is also the most studied member of this family. The EGFR is encoded by the ErbB gene, mapped to chromosome 7 q22. These receptors are attached to the cytoplasmic membrane and consist of an ectodomain (ECD), comprising of four subdomains called DI-DIV, a hydrophobic transmembrane domain, and an intracytoplasmic tyrosine kinase domain.
Biokémiai/fiziológiai hatások
EGF exerts its actions by binding to the EGF receptor (EGFR), a 170 kDa glycoprotein having EGF-activated protein tyrosine kinase activity. Even in the absence of EGF-like ligands, EGFR can participate in cellular responses elicited by several other stimuli. High levels of EGFR are expressed in approximately one third of human epithelial tumors, and in the cancers of the bladder, breast or lung that have poor clinical prognosis, hence the interest in targeting EGFR.
Epidermal growth factor receptor (EGFR) has an essential role in normal developmental processes, and is mutated in multiple cancers. It is involved in the pathogenesis of epidermoid tumors, and thus, has extreme importance as a cancer therapeutic target. Gefitinib (GEF) and erlotinib act as EGFR inhibitors, and induce apoptosis in non-small cell lung cancer (NSCLC) cells. A truncated isoform, called EGFRvIII is linked to multiple cases of head and neck squamous cell carcinoma (HNSCC). In ∼40% of glioblastoma multiforme (GBM), this gene is amplified.
Egység definíció
One unit (U) of the enzyme is defined as the amount needed to incorporate 1 pmol of phosphate into the substrate (KVEKIGEGTYGVVYK: 6 - 20 residue of p34cdc2) in 1 minute.
Fizikai forma
Lyophilized from a solution in 50 mM HEPES, pH 7.6, 150 mM NaCl, 0.05% Triton X-100, 1 mM dithiothreitol, and 10% trehalose.
Elkészítési megjegyzés
Affinity purified from human carcinoma A431 cells.
kapcsolódó termék
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Analitikai tanúsítványok (COA)
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A comprehensive pathway map of epidermal growth factor receptor signaling
Oda K, et al.
Molecular Systems Biology (2005)
Qian Gou et al.
Oncogene, 39(25), 4844-4853 (2020-05-23)
In response to nutrient deficiency, autophagy degrades cytoplasmic materials and organelles in lysosomes, which is nutrient recycling, whereas activation of EGFR mediates autophagy suppression in response to growth factors. It is unclear whether PPARδ could be the regulator of autophagy
EGFR/MDM2 signaling promotes NF-?B activation via PPAR? degradation
Xu Y, et al.
Carcinogenesis, 37(2), 215-222 (2016)
Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways
Wee P and Wang Z
Cancers, 9(5), 52-52 (2017)
Sarah E Wheeler et al.
PloS one, 10(2), e0117781-e0117781 (2015-02-07)
Head and neck squamous cell carcinoma (HNSCC) accounts for more than 5% of all cancers worldwide. The mortality rate of HNSCC has remained unchanged (approximately 50%) over the last few decades. Ubiquitous overexpression of wild type EGFR in many solid
Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.
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