E2011

cis-5,8,11,14,17-Eicosapentaenoic acid

from fish oil, ≥99% (GC), liquid, 5-Lipoxygenase inhibitor

• Szinonimák: EPA, Timnodonic acid
• Lineáris képlet: CH₃(CH₂CH=CH)₅(CH₂)₃CO₂H
• CAS-szám: 10417-94-4
• Molekulatömeg: 302.45
• Beilstein: 1714433
• MDL-szám: MFCD00065716
• UNSPSC kód: 12352211
• PubChem Substance ID: 24894450
• NACRES: NA.77

Tulajdonságok

• product name: cis-5,8,11,14,17-Eicosapentaenoic acid, ≥99%
• biológiai forrás: fish oil
• Minőségi szint: 200
• Teszt: ≥99%
• form: liquid
• törésmutató: n20/D 1.4977 (lit.)
• mp: −54-−53 °C (lit.)
• oldhatóság: methanol: 50 mg/mL, clear, colorless
• sűrűség: 0.943 g/mL at 25 °C (lit.)
• tárolási hőmérséklet: −20°C
• SMILES string: CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O
• InChI: 1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
• Nemzetközi kémiai azonosító kulcs: JAZBEHYOTPTENJ-JLNKQSITSA-N
• Géninformáció: human ... ALOX5(240) ; mouse ... ALOX5(11689) , Pparg(19016) ; rat ... ALOX5(25290)

Leírás

Általános leírás

Eicosapentaenoic acid is a polyunsaturated fatty acid (PUFAs) and is synthesized from linolenic acid. It is distributed in phospholipid bilayers of the cell membrane, synaptic membranes of the brain and retina. It is obtained majorly from fish oil, seaweed, phytoplankton, and camelina. Being an Omega-3 fatty acid, it shows cis-trans conformations.

Alkalmazás

cis-5,8,11,14,17-Eicosapentaenoic acid has been used:

• to test pharmacologic effect on steatosis in hepatocytes
• as an analytical standard in Raman spectra measurements to characterize human breast cancer samples
• in lipid peroxidation assay in mouse embryonic fibroblasts and in pre-treatment of cells for cell viability studies

Biokémiai/fiziológiai hatások

Eicosapentaenoic acid (EPA) is essential for healthy living and alleviates obesity. It decreases the triglyceride levels by modulating very-low-density lipoprotein(VLDL) levels.

5-Lipoxygenase inhibitor; reduces thromboxane A₂ production.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 3
• Lobbanási pont (F): 200.1 °F - closed cup
• Lobbanási pont (C): 93.4 °C - closed cup
• Egyéni védőeszköz: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter