A9525

Angiotensin II human

≥93% (HPLC), powder

• Szinonimák: 1-8-AngiotensinI, 5-Isoleucine-angiotensinII, Ang II, Angiotensin 2, Angiotensin II, DRVYIHPF, Hypertensin, Ile(5)-angiotensinII
• Tapasztalati képlet (Hill-képlet): C₅₀H₇₁N₁₃O₁₂
• CAS-szám: 4474-91-3
• Molekulatömeg: 1046.18
• MDL-szám: MFCD00161484
• UNSPSC kód: 12352202
• eCl@ss: 42020611
• PubChem Substance ID: 24891466
• NACRES: NA.32

Tulajdonságok

• biológiai forrás: synthetic
• Minőségi szint: 300
• Teszt: ≥93% (HPLC)
• Forma: powder
• tárolási körülmény: (Keep container tightly closed in a dry and well-ventilated place)
• koncentráció: ≤100%
• technika/technikák: cell culture | mammalian: suitable
• szennyeződések: 1.2-10.4% acetate
• oldhatóság: water: 25 mg/mL, clear, colorless
• UniProt elérési szám: P01019
• tárolási hőmérséklet: −20°C
• SMILES string: [nH]1cncc1C[C@H](NC(=O)C(NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)CCCNC(=N)N)C(C)C)Cc4ccc(cc4)O)[C@H](CC)C)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](Cc3ccccc3)C(=O)O
• InChI: 1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41?/m0/s1
• Nemzetközi kémiai azonosító kulcs: CZGUSIXMZVURDU-GYGDIBSWSA-N
• Géninformáció: human ... AGT(183)

Leírás

Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe

Általános leírás

Research area: Cell Signaling

Alkalmazás

• Angiotensin II (angII) human has been used:
• to study its effect on interleukin-1β–mediated islet inflammation and β-cell dysfunction.
• to determine if angII activates specific calcineurin-dependent NFAT (nuclear factor of activated T-cells) isoforms in cardiomyocytes.
• to study the actions of systemic angII infusions on glomerular permeability in vivo.
• to induce abdominal aortic aneurysms (AAAs) in ApoE knockout mice for experimental studies.
• to study the effect of Ang II infusion on atrial branched-chain amino acids (BCAAs) catabolism in male C57/BL6 mice.
• to check the effects of angII on plasma triglyceride production and its association with insulin resistance in normal rats.

Biokémiai/fiziológiai hatások

Angiotensin II (angII) is an octapeptide cardiovascular hormone which affects the activities of the heart, kidney, vasculature and brain. AngII in the blood is produced from angiotensinogen via renin and angiotensin converting enzyme (ACE). It works via binding to specific receptors present on cell membranes. It is associated with vasoconstriction, induction of vascular smooth muscle cell growth, stimulation of protooncogene expression, and modulation of myocardial hypertrophy, renal failure and fibrosisAngII plays a key role in the regulation of blood pressure via the renin-angiotensin-aldosterone (RAAS) pathway.

Tulajdonságok és előnyök

The purity of our angiotensin II human, Ang II, is verified to assure your experimental success (HPLC and peptide content). The peptide sequence is DRVYIHPF.

Antitest adszorbens

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH · 2CH₃COOH · H₂O

Analízis megjegyzés

Peptide content not less than 75%

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)