C1389

Carbenicillin disodium salt

89.0-100.5% anhydrous basis

• Szinonimák: Carbenicillin, Disodium carbenicillin, α-Carboxybenzylpenicillin disodium salt
• Tapasztalati képlet (Hill-képlet): C₁₇H₁₆N₂Na₂O₆S
• CAS-szám: 4800-94-6
• Molekulatömeg: 422.36
• Beilstein: 5722128
• EC-szám: 225-360-8
• MDL-szám: MFCD00077683
• UNSPSC kód: 51282413
• PubChem Substance ID: 24892409
• NACRES: NA.76

Tulajdonságok

• biológiai forrás: synthetic (chemical)
• Minőségi szint: 200
• Teszt: 89.0-100.5% anhydrous basis
• form: powder
• szín: white to off-white
• oldhatóság: H₂O: 50 mg/mL
• antibiotikus hatásspektrum: Gram-negative bacteria; Gram-positive bacteria
• Hatásmechanizmus: cell wall synthesis | interferes
• tárolási hőmérséklet: 2-8°C
• SMILES string: [Na+].[Na+].CC1(C)S[C@@H]2[C@H](NC(=O)C(C([O-])=O)c3ccccc3)C(=O)N2[C@H]1C([O-])=O
• InChI: 1S/C17H18N2O6S.2Na/c1-17(2)11(16(24)25)19-13(21)10(14(19)26-17)18-12(20)9(15(22)23)8-6-4-3-5-7-8;;/h3-7,9-11,14H,1-2H3,(H,18,20)(H,22,23)(H,24,25);;/q;2*+1/p-2/t9?,10-,11+,14-;;/m1../s1
• Nemzetközi kémiai azonosító kulcs: RTYJTGSCYUUYAL-YCAHSCEMSA-L

Leírás

Általános leírás

Carbenicillin is a semi-synthetic, broad-spectrum carboxypenicillin antibiotic with bactericidal and beta-lactamase resistant activity. It is a broad-spectrum antibiotic, meaning that it is effective against a wide range of bacteria, including both Gram-positive and Gram-negative bacteria. Carbenicillin is particularly useful against Pseudomonas aeruginosa, a Gram-negative bacterium that is often resistant to other antibiotics.

Carbenicillin is commonly used in cell biology applications to prevent the growth of bacterial contaminants. It is also used in microbiology to select for bacteria that have been transformed with a vector harboring the gene encoding beta-lactamase, which makes them resistant to carbenicillin.

Alkalmazás

Carbenicillin disodium salt has been used:

• in the preparation of Luria-Bertani (LB) agar plates and media
• as a selective agent in the culture media to prevent the growth of bacterial contaminants
• in a study focused on the development of monoclonal antibodies

Biokémiai/fiziológiai hatások

Carbenicillin acylates the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation prevents the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall synthesis and eventually causes cell lysis.

Mode of Action: Carboxypenicillin antibiotic that inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane.


Antimicrobial spectrum: Active against Gram-positive and Gram-negative bacteria

Tulajdonságok és előnyök

• Broad-spectrum antibiotic with bactericidal and beta-lactamase resistant activity
• Effective against a wide range of bacteria, including Pseudomonas aeruginosa
• Commonly used in Cell Biology and Biochemical applications
• Offers greater stablility than ampicillin

Tárolás és stabilitás

Tightly closed. Dry. Keep locked up or in an area accessible only to qualified or authorized

Analízis megjegyzés

Stable at 37 °C for 3 days

Egyéb megjegyzések

For additional information on our range of Biochemicals, please complete this form.

Keep container tightly closed in a dry and well-ventilated place.

Biztonsági adatok

• Piktogramok: GHS08
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H317,H334
• Óvintézkedésre vonatkozó mondatok: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Veszélyességi osztályok: Resp. Sens. 1 - Skin Sens. 1
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: dust mask type N95 (US), Eyeshields, Faceshields, Gloves