1.01544

L-Arginine monohydrochloride

EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

• Szinonimák: α-Amino-δ-guanidino valerianic acid hydrochloride, alpha-Amino-delta-guanidino valerianic acid hydrochloride, Arg, (S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, (S)-(+)-Arginine hydrochloride
• Tapasztalati képlet (Hill-képlet): C₆H₁₄N₄O₂ · HCl
• CAS-szám: 1119-34-2
• Molekulatömeg: 210.66
• Beilstein: 3631658
• MDL-szám: MFCD00064550
• UNSPSC kód: 12352209
• EC index szám: 214-275-1

Tulajdonságok

• Ügynökség: BP; ChP; JP; Ph. Eur.; USP
• Minőségi szint: 500
• gőznyomás: <1 Pa ( 20 °C)
• termékcsalád: EMPROVE^® EXPERT
• Teszt: 98.5-101.0% dry basis (perchloric acid titration)
• Forma: solid
• pH: 5.7 (20 °C, 100 g/L in H₂O)
• mp: >235 °C
• oldhatóság: water: 730 g/L at 20 °C
• sűrűség: 1.42 g/cm³ at 20 °C
• anion nyomok: chloride (Cl^-): 16.5-17.1%; sulfate (SO₄^2-): ≤200 ppm
• kation nyomok: As: ≤2 ppm; Fe: ≤10 ppm; NH₄⁺: ≤200 ppm; heavy metals (as Pb): ≤10 ppm
• alkalmazás(ok): liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical
• tárolási hőmérséklet: 2-30°C
• SMILES string: Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O
• InChI: 1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1
• Nemzetközi kémiai azonosító kulcs: KWTQSFXGGICVPE-WCCKRBBISA-N

Leírás

Általános leírás

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Alkalmazás

Arginine hydrochloride has several applications in biopharma manufacturing such as an additive for protein refolding, aggregate suppression and buffer for chromatography.
Due to its low microbial and endotoxin limits, L-Arginine monohydrochloride Emprove^® Expert is suitable for high-risk applications.

Biokémiai/fiziológiai hatások

Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Jogi információk

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable