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Merck
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A4474

SAFC

L-Arginine

Gyógyszeripari előállítás

Szinonimák:

(S)-2-Amino-5-guanidinopentanoic acid

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)

About This Item

Lineáris képlet:
H2NC(=NH)NH(CH2)3CH(NH2)CO2H
CAS-szám:
74-79-3
Molekulatömeg:
174.20
Beilstein:
1725413
EC-szám:
200-811-1
MDL-szám:
MFCD00002635
UNSPSC kód:
12352209
eCl@ss:
32160406
NACRES:
NA.26

biológiai forrás

non-animal source

Minőségi szint

400

Teszt

>98.5%

form

crystalline powder

technika/technikák

cell culture | mammalian: suitable

szennyeződések

endotoxin, heavy metals, trace metals, residual solvents, tested

mp

222 °C (dec.) (lit.)

oldhatóság

H2O: 100 mg/mL

alkalmasság

suitable for manufacturing use

alkalmazás(ok)

pharmaceutical (small molecule)

SMILES string

N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1

Nemzetközi kémiai azonosító kulcs

ODKSFYDXXFIFQN-BYPYZUCNSA-N

Géninformáció

human ... NOS1(4842) , NOS2(4843)
rat ... Ppm1a(24666)

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Általános leírás

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.

Alkalmazás

L-Arginine is a non-essential amino acid. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

Biokémiai/fiziológiai hatások

Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Jogi információk

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Tárolási osztály kódja

13 - Non Combustible Solids

WGK

WGK 1

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Egyéni védőeszköz

Eyeshields, Gloves, type N95 (US)

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

Már rendelkezik ezzel a termékkel?

Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Krishnan Suresh Kumar et al.
European journal of medicinal chemistry, 45(11), 5474-5479 (2010-08-21)
A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex
Ahmed Moursy et al.
Nucleic acids research, 42(10), 6659-6672 (2014-04-03)
Regulation of SMN2 exon 7 splicing is crucial for the production of active SMN protein and the survival of Spinal Muscular Atrophy (SMA) patients. One of the most efficient activators of exon 7 inclusion is hnRNP G, which is recruited
Jia-Yi Dong et al.
American heart journal, 162(6), 959-965 (2011-12-06)
Previous studies suggest that L-arginine, an amino acid and a substrate of nitric oxide synthase, may have blood pressure (BP)-lowering effect. Because some studies were performed with limited number of patients with hypertension and therefore limited statistical power with sometimes
Diane N Singhroy et al.
Retrovirology, 10, 73-73 (2013-07-23)
Protein arginine methyltransferase 6 (PRMT6) is a nuclear enzyme that methylates arginine residues on histones and transcription factors. In addition, PRMT6 inhibits HIV-1 replication in cell culture by directly methylating and interfering with the functions of several HIV-1 proteins, i.e.
Hartmut Grasemann et al.
Current pharmaceutical design, 18(5), 726-736 (2012-01-11)
The concentrations of nitric oxide are decreased in airways of patients with cystic fibrosis. The reasons for this nitric oxide deficiency are incompletely understood but may include reduced production from nitric oxide synthases due to decreased expression, the enzymes in
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