902551

BocNH-PEG4-acid

• Szinonimák: 2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-19-oic acid, Boc-NH-PEG4-CH₂COOH
• Tapasztalati képlet (Hill-képlet): C₁₅H₂₉NO₈
• CAS-szám: 876345-13-0
• Molekulatömeg: 351.39
• MDL-szám: MFCD30528568
• UNSPSC kód: 12352106
• NACRES: NA.22
• Forma: liquid

Tulajdonságok

• Forma: liquid
• reakcióalkalmasság: reaction type: Pegylations; reagent type: cross-linking reagent
• törésmutató: n/D 1.4641
• sűrűség: 1.1395 g/mL
• funkcionális csoport: Boc; amine; carboxylic acid
• tárolási hőmérséklet: −20°C
• SMILES string: OC(COCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
• InChI: 1S/C15H29NO8/c1-15(2,3)24-14(19)16-4-5-20-6-7-21-8-9-22-10-11-23-12-13(17)18/h4-12H2,1-3H3,(H,16,19)(H,17,18)

Leírás

Alkalmazás

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation

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Egyéb megjegyzések

A Hexylchloride-Based Catch-and-Release System for Chemical Proteomic Applications

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Jogi információk

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable