902675

BocNH-PEG₆-acid

• Szinonimák: 2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid, Boc-NH-PEG6-CH₂COOH
• Tapasztalati képlet (Hill-képlet): C₁₉H₃₇NO₁₀
• CAS-szám: 391684-36-9
• Molekulatömeg: 439.50
• MDL-szám: MFCD30489670
• UNSPSC kód: 12352106
• NACRES: NA.22

Tulajdonságok

• Forma: liquid
• reakcióalkalmasság: reagent type: linker
• törésmutató: n/D 1.4657
• funkcionális csoport: Boc; amine; carboxylic acid
• tárolási hőmérséklet: −20°C
• SMILES string: OC(COCCOCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
• InChI: 1S/C19H37NO10/c1-19(2,3)30-18(23)20-4-5-24-6-7-25-8-9-26-10-11-27-12-13-28-14-15-29-16-17(21)22/h4-16H2,1-3H3,(H,20,23)(H,21,22)
• Nemzetközi kémiai azonosító kulcs: ZKCDWMFMVAYYED-UHFFFAOYSA-N

Leírás

Alkalmazás

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG₆-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Egyéb megjegyzések

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Jogi információk

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable