902683

BocNH-PEG5-acid

• Szinonimák: 2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azadocosan-22-oic acid, Boc-NH-PEG5-CH₂COOH
• Tapasztalati képlet (Hill-képlet): C₁₇H₃₃NO₉
• CAS-szám: 890152-41-7
• Molekulatömeg: 395.45
• MDL-szám: MFCD31656900
• UNSPSC kód: 12352106
• NACRES: NA.22
• Forma: liquid

Tulajdonságok

• Forma: liquid
• reakcióalkalmasság: reaction type: Pegylations; reagent type: cross-linking reagent
• funkcionális csoport: Boc; amine; carboxylic acid
• tárolási hőmérséklet: −20°C
• SMILES string: OC(COCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
• InChI: 1S/C17H33NO9/c1-17(2,3)27-16(21)18-4-5-22-6-7-23-8-9-24-10-11-25-12-13-26-14-15(19)20/h4-14H2,1-3H3,(H,18,21)(H,19,20)

Leírás

Alkalmazás

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG5-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Jogi információk

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable