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SAE0073

Saponin

Synonym(s):

Surfactant Saponin

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About This Item

UNSPSC Code:
12161902
EC Number:
232-462-6
NACRES:
NA.21
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description

non-ionic

Quality Segment

composition

Sapogenin content, 20-35%

technique(s)

HPLC: suitable, LC/MS: suitable, protein quantification: suitable

sulfated ash

≤10%

Application

Saponins has been used to permeabilize dendritic cells (DCs) for intracellular staining with antibodies.

Biochem/physiol Actions

Saponins are associated with many biological and pharmacological activities. It is known to stimulate immune response in mammals. Saponins possesses antiviral, antifungal, antitumor, anti-inflammatory, hypoglycemic and hypocholesterolemic effects. It is a potent hemolytic, when injected intravaneously. It is also useful as a surfactant to enhance penetration of proteins and other macromolecules through cell membranes. Saponins have also been used as adjuvants for vaccines.

Packaging

10, 25 g in poly bottle

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This Item
4703684510558255
technique(s)

HPLC: suitable, protein quantification: suitable, LC/MS: suitable

technique(s)

HPLC: suitable, protein quantification: suitable

technique(s)

HPLC: suitable, protein quantification: suitable

technique(s)

-

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

100

description

non-ionic

description

-

description

-

description

Merck USA index - 14, 8365

composition

Sapogenin content, 20-35%

composition

Sapogenin, 8-25%

composition

Sapogenin, 8-25%

composition

-

sulfated ash

≤10%

sulfated ash

-

sulfated ash

-

sulfated ash

-


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable



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Flavia Radogna et al.
Methods in molecular biology (Clifton, N.J.), 2276, 129-141 (2021-06-02)
Cellular energy metabolism is regulated by complex metabolic pathways. Although anaerobic glycolysis was reported as a primary source of energy in cancer leading to a high rate of lactate production, current evidence shows that the main energy source supporting cancer
Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation
Gotoh K, et al.
Cell Reports, 25(7), 1800-1815 (2018)
Sónia A Pinho et al.
The FEBS journal, 289(17), 5198-5217 (2022-02-26)
Cell culture conditions highly influence cell metabolism in vitro. This is relevant for preclinical assays, for which fibroblasts are an interesting cell model, with applications in regenerative medicine, diagnostics and therapeutic development for personalized medicine, and the validation of ingredients for



Global Trade Item Number

SKUGTIN
SAE0073-25G04061833493458
SAE0073-10G04061833343395

Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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