B7166
5-Bromouridine 5′-triphosphate sodium salt
≥93%, synthetic (organic), powder
Synonym(s):
5-BrUTP
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About This Item
Empirical Formula (Hill Notation):
C9H14BrN2O15P3 · xNa+
CAS Number:
Molecular Weight:
563.04 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
Assay:
≥93%
Biological source:
synthetic (organic)
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C
Product Name
5-Bromouridine 5′-triphosphate sodium salt, ≥93%
biological source
synthetic (organic)
Quality Level
assay
≥93%
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
OP(OP(OP(O)(O)=O)(O)=O)(OC[C@H]1O[C@@H](N(C=C2Br)C(NC2=O)=O)[C@H](O)[C@@H]1O)=O.[Na]
InChI
1S/3Na/q3*+1
InChI key
BVPYARCRLTXGBD-UHFFFAOYSA-N
General description
5-Bromouridine 5′-triphosphate (5-BrUTP) is used to measure transcription via labeling of ribonucleic acids (RNA). RNA or cells labeled via 5-BrUTP incorporation may be detected immunologically with antibodies.
Application
5-Bromouridine 5′-triphosphate (5-BrUTP) is used to measure transcription via labeling of ribonucleic acids (RNA). RNA or cells labeled via 5-BrUTP incorporation may be detected immunologically with antibodies.
5-Bromouridine 5′-triphosphate sodium salt has been used:
- to infer the chromosome intermingling between embryonic stem (ES) cells (differentiated and undifferentiated) and terminally differentiated NIH3T3 cells
- to label nascent RNA in in vivo transcription analysis using fibroblasts
- and transfected MDA-MB-231 cells
- to label RNA for nuclear run-on experiments
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Bianca S Heinrich et al.
PLoS pathogens, 6(6), e1000958-e1000958 (2010-06-30)
Positive-strand and double-strand RNA viruses typically compartmentalize their replication machinery in infected cells. This is thought to shield viral RNA from detection by innate immune sensors and favor RNA synthesis. The picture for the non-segmented negative-strand (NNS) RNA viruses, however
Hong-Thuy Bui et al.
Reproduction (Cambridge, England), 141(1), 67-77 (2010-10-27)
Several lines of evidence indicate that the formation of a transcriptionally repressive state during the two-cell stage in the preimplantation mouse embryo is superimposed on the activation of the embryonic genome. However, it is difficult to determine the profile of
Claire Tolza et al.
Molecular cancer research : MCR, 17(10), 1999-2014 (2019-07-14)
The architectural chromatin protein HMGA1 and the transcription factor Fra-1 are both overexpressed in aggressive triple-negative breast cancers (TNBC), where they both favor epithelial-to-mesenchymal transition, invasion, and metastasis. We therefore explored the possibility that Fra-1 might be involved in enhanced
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B7166-50MG | 04061833002155 |
| B7166-5MG | 04061833441596 |
| B7166-10MG | 04061833002148 |