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Methimazole

Name: Methimazole
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1-Methyl-2-imidazolethiol, 2-Mercapto-1-methylimidazole

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About This Item

Empirical Formula (Hill Notation):

C₄H₆N₂S

CAS Number:

60-56-0

Molecular Weight:

114.17

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329750399

MDL number:

MFCD00179321

Beilstein/REAXYS Number:

108646

eCl@ss:

39161002

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Properties

grade

pharmaceutical primary standard

API family

methimazole

manufacturer/tradename

USP

mp

144-147 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CN1C=CNC1=S

InChI

1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)

InChI key

PMRYVIKBURPHAH-UHFFFAOYSA-N

Gene Information

human ... TPO(7173)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Methimazole USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

Methimazole Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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1 of 1

This Item	46429	M8506	Y0000336
USP 1411005 Methimazole	Supelco 46429 Methimazole	Supelco M8506 Methimazole	Y0000336 Thiamazole
grade pharmaceutical primary standard	grade analytical standard	grade analytical standard	grade pharmaceutical primary standard
manufacturer/tradename USP	manufacturer/tradename -	manufacturer/tradename -	manufacturer/tradename EDQM
application(s) pharmaceutical (small molecule)	application(s) cleaning products clinical cosmetics food and beverages forensics and toxicology personal care pharmaceutical (small molecule)	application(s) cleaning products cosmetics food and beverages forensics and toxicology personal care pharmaceutical (small molecule) veterinary	application(s) pharmaceutical (small molecule)
format neat	format neat	format neat	format neat
API family methimazole	API family -	API family -	API family thiamazole
mp 144-147 °C (lit.)	mp 144-147 °C (lit.)	mp 144-147 °C (lit.)	mp 144-147 °C (lit.)

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pictograms

GHS08,GHS07

pcodes

P202 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313

flash_point_f

Not applicable

flash_point_c

Not applicable

target_organs

Endocrine system

signalword

Danger

hcodes

H302,H317,H319,H360D,H373

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1A - Skin Sens. 1 - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

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Successful treatment of thyroid storm with plasmapheresis in a patient with methimazole-induced agranulocytosis.

Ashish A Vyas et al.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 16(4), 673-676 (2010-05-05)

To report a case of a patient with Graves disease presenting with agranulocytosis induced by methimazole, with subsequent thyroid storm and successful therapeutic use of plasmapheresis. The clinical features and laboratory findings in a patient with agranulocytosis and thyroid storm

Remission of Graves' hyperthyroidism treated with methimazole.

Fernando Bolaños et al.

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 54(4), 307-310 (2002-11-06)

Long-term thionamide treatment is considered one of the main resources for Graves' hyperthyroidism. Although a 54.2% remission rate in patients so treated in Mexico was previously reported, most articles have shown a wide variation over time. In the present article

Diphenyl diselenide modulates gene expression of antioxidant enzymes in the cerebral cortex, hippocampus and striatum of female hypothyroid rats.

Glaecir Roseni Mundstock Dias et al.

Neuroendocrinology, 100(1), 45-59 (2014-07-12)

Cellular antioxidant signaling can be altered either by thyroid disturbances or by selenium status. To investigate whether or not dietary diphenyl diselenide can modify the expression of genes of antioxidant enzymes and endpoint markers of oxidative stress under hypothyroid conditions.

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Global Trade Item Number

SKU	GTIN
1411005-200MG	04061833860526

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