M8506

Methimazole

analytical standard

• Synonym(s): 1-Methyl-2-mercaptoimidazole, MET, 1-Methyl-2-imidazolethiol, 2-Mercapto-1-methylimidazole
• Empirical Formula (Hill Notation): C₄H₆N₂S
• CAS Number: 60-56-0
• Molecular Weight: 114.17
• Beilstein: 108646
• EC Number: 200-482-4
• MDL number: MFCD00179321
• UNSPSC Code: 41116107
• eCl@ss: 39161002
• PubChem Substance ID: 329818061
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 200
• Assay: ≥99%
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 144-147 °C (lit.)
• application(s): cleaning products; cosmetics; food and beverages; forensics and toxicology; personal care; pharmaceutical (small molecule); veterinary
• format: neat
• SMILES string: CN1C=CNC1=S
• InChI: 1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
• InChI key: PMRYVIKBURPHAH-UHFFFAOYSA-N
• Gene Information: human ... TPO(7173)

Description

General description

Methimazole belongs to the chemical class of thioureylene compounds, used as an anti-thyroid drug in the management of hyperthyroidism.

Application

Beclomethasone dipropionate analytical standard can be used as follows:

• Silver/graphene-modified carbon-paste electrode (AgGCPE) based electrochemical determination of methimazole
• Development of a surface-enhanced Raman scattering (SERS) based method to estimate propylthiouracil and methimazole using sodium alginate-protected silver nanoparticles as SERS substrate
• Detection of methimazole at ultra-trace limits using surface-enhanced Raman spectroscopy based on gold nanoparticles (AuNPs) substrate
• Quantitative analysis of human blood samples for methimazole using high-performance liquid chromatography-tandem mass spectrometric (HPLC-MS/MS) method
• Electrochemical determination of methimazole in pharmaceutical tablet and human blood serum samples by molecularly imprinted polymer (MIP)- pencil graphite electrode (PGE) based sensor

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Warning
• Hazard Statements: H302,H317,H319,H361fd
• Precautionary Statements: P202 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves