The stability of this product in solution after reconstitution has not been specifically determined. However, it is recommended that solutions be stored in working aliquots at −20°C. This practice is considered optimal for maintaining stability, but no exact shelf life duration is provided after reconstitution.
H4001
Hydrocortisone
synthetic (organic), ≥98% (HPLC), anti-inflammatory agent, powder
Hydrocortisone
Synonym(s):
11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M
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About This Item
Empirical Formula (Hill Notation):
C21H30O5
CAS Number:
Molecular Weight:
362.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
200-020-1
MDL number:
Beilstein/REAXYS Number:
1354819
Pricing and availability is not currently available.
Product Name
Hydrocortisone, ≥98% (HPLC)
biological source
synthetic (organic)
Quality Level
sterility
non-sterile
assay
≥98% (HPLC)
form
powder
mp
211-214 °C (lit.)
solubility
water: 0.28 g/L at 25 °C
application(s)
cell analysis
shipped in
ambient
storage temp.
room temp
SMILES string
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
InChI
1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChI key
JYGXADMDTFJGBT-VWUMJDOOSA-N
Gene Information
human ... ABCB1(5243), CYP3A4(1576), NR3C1(2908), SERPINA6(866)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126)
rat ... Ar(24208), Nr3c1(24413)
Biochem/physiol Actions
Primary glucocorticoid secreted by the adrenal cortex.
Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.
Features and Benefits
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay 97.0-102.0% dry basis | assay ≥98% | assay - |
| form powder | form powder | form powder | form liquid |
| Quality Level 300 | Quality Level 300 | Quality Level 200 | Quality Level 500 |
| storage temp. room temp | storage temp. - | storage temp. room temp | storage temp. −20°C |
| solubility water: 0.28 g/L at 25 °C | solubility water: soluble 0.28 g/L at 25 °C | solubility chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to very faintly yellow | solubility - |
| shipped in ambient | shipped in - | shipped in ambient | shipped in dry ice |
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signalword
Danger
hcodes
Hazard Classifications
Repr. 1A - STOT RE 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Florian Hardeveld et al.
Psychoneuroendocrinology, 50, 62-71 (2014-09-03)
Although HPA-axis activity has been studied extensively in relation to depression, there is no consensus whether HPA-axis parameters predicts major depressive disorder (MDD) recurrence. We investigated whether HPA-axis parameters (cortisol awakening response (CAR), the dexamethasone suppression test (DST) and evening
Liselotte van Bloemendaal et al.
Diabetes, 63(12), 4186-4196 (2014-07-30)
Gut-derived hormones, such as GLP-1, have been proposed to relay information to the brain to regulate appetite. GLP-1 receptor agonists, currently used for the treatment of type 2 diabetes (T2DM), improve glycemic control and stimulate satiety, leading to decreases in
K J Rademaker et al.
Archives of disease in childhood. Fetal and neonatal edition, 93(1), F58-F63 (2007-09-13)
The benefits versus the risks of postnatal administration of steroids in preterm-born infants are still debatable. This review examines the literature on postnatal hydrocortisone treatment for chronic lung disease (CLD) in preterm-born infants with a particular focus on the effects
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H4001-100G | 04061833794418 |
| H4001-1G | 04061833794432 |
| H4001-5G | 04061833794463 |
| H4001-10G | 04061833794425 |
| H4001-25G | 04061833794456 |
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What is the shelf life of reconstituted product at 4C, -20C, and -80C?
1 answer-
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