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49761

Spermidine

analytical standard

Synonym(s):

1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane

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About This Item

Linear Formula:
NH2(CH2)3NH(CH2)4NH2
CAS Number:
124-20-9
Molecular Weight:
145.25
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
329757521
EC Number:
204-689-0
Beilstein/REAXYS Number:
1698591
MDL number:
MFCD00008229
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grade

analytical standard

Quality Level

100

assay

≥97.5% (NT), ≥99.0% (GC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

refractive index

n20/D 1.479 (lit.)

density

0.925 g/mL at 25 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

storage temp.

2-8°C

SMILES string

NCCCCNCCCN

InChI

1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

InChI key

ATHGHQPFGPMSJY-UHFFFAOYSA-N

General description

Spermidine is a naturally occurring polyamine compound commonly found in food. It is essential for cell growth and survival.

Application

Spermidine may be used as one of the reference standard for the determination of spermidine in biological samples by high performance liquid chromatography-electrospray ionization–ion trap tandem mass spectrometry (HPLC–ESI–ITMS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T4 polynucleotide kinase activity.
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Disclaimer

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

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Spermidine analytical standard

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49761

Spermidine

Spermidine BioReagent, Molecular Biology, suitable for cell culture, ≥98%

Sigma-Aldrich

S0266

Spermidine

Spermidine BioUltra, Molecular Biology, ≥99.5% (GC)

Sigma-Aldrich

85558

Spermidine

Spermidine ≥99% (GC)

Sigma-Aldrich

S2626

Spermidine

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

ChIP: suitable, buffer exchange: suitable

technique(s)

-

grade

analytical standard

grade

Molecular Biology

grade

Molecular Biology

grade

-

format

neat

format

-

format

-

format

-

application(s)

cleaning products
cosmetics
food and beverages
personal care

application(s)

-

application(s)

advanced drug delivery
genomic analysis

application(s)

-

density

0.925 g/mL at 25 °C (lit.)

density

0.925 g/mL at 25 °C (lit.)

density

0.925 g/mL at 25 °C (lit.)

density

0.925 g/mL at 25 °C (lit.)

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

-

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pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

233.6 °F - closed cup

flash_point_c

112 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN3302
BCCL5588
BCCM4979
BCCK7415
BCCH5039

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Micro-scale strategy to detect spermine and spermidine by MALDI?TOF MS in foods and identification of apoptosis-related proteins by nano-flow UPLC?MS/MS after treatment with spermine and spermidine
Su H H, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 978, 131-137 (2015)
Determination of putrescine, cadaverine, spermidine and spermine in different chemical matrices by high performance liquid chromatography?electrospray ionization?ion trap tandem mass spectrometry (HPLC?ESI?ITMS/MS).
Ibarra A A G, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1002, 176-184 (2015)
Eugenia Morselli et al.
Aging, 1(12), 961-970 (2010-02-17)
Although autophagy has widely been conceived as a self-destructive mechanism that causes cell death, accumulating evidence suggests that autophagy usually mediates cytoprotection, thereby avoiding the apoptotic or necrotic demise of stressed cells. Recent evidence produced by our groups demonstrates that
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Global Trade Item Number

SKUGTIN
49761-100MG04061832418094

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Hello, I have a quick question about product # 49761. Would this be proficient for mica surface modification? Thanks.

    1 answer

    1. Spermidine can be used for mica surface modification, but Product 49761-100MG is just an analytical standard. For mica surface modification, it is rather recommended to use Product 85558-1G.

      Helpful?

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