F6300
Flumazenil
>99% (HPLC), solid, benzodiazepine receptor antagonist
Synonym(s):
Ro 15-1788, Ro15-1788
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About This Item
Empirical Formula (Hill Notation):
C15H14FN3O3
CAS Number:
Molecular Weight:
303.29
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Pricing and availability is not currently available.
Product Name
Flumazenil, >99% (HPLC), solid
Quality Level
assay
>99% (HPLC)
form
solid
color
white
originator
Roche
storage temp.
2-8°C
SMILES string
CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(F)ccc-23
InChI
1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
InChI key
OFBIFZUFASYYRE-UHFFFAOYSA-N
Gene Information
General description
Flumazenil reverses sedative and hypnotic effects of benzodiazepines. It is used to increase acquisition, enhance retention and treat amnesia in mice.
Biochem/physiol Actions
Highly specific benzodiazepine receptor antagonist.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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| assay >99% (HPLC) | assay - | assay ≥99% (HPLC) | assay - |
| form solid | form - | form solid | form - |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level 300 |
| storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C | storage temp. 2-30°C |
| color white | color - | color white | color - |
| originator Roche | originator - | originator - | originator - |
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Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Nahid Amini et al.
Analytical and bioanalytical chemistry, 405(4), 1303-1310 (2012-11-28)
A general method is presented for the identification of radiometabolites in plasma of human and monkey subjects after administration of positron emission tomography (PET) radioligands. The radiometabolites are first produced in vitro, using liver microsomes, subsequently separated using fast radio-liquid
David B Rye et al.
Science translational medicine, 4(161), 161ra151-161ra151 (2012-11-24)
The biology underlying excessive daytime sleepiness (hypersomnolence) is incompletely understood. After excluding known causes of sleepiness in 32 hypersomnolent patients, we showed that, in the presence of 10 μM γ-aminobutyric acid (GABA), cerebrospinal fluid (CSF) from these subjects stimulated GABA(A)
Suengmok Cho et al.
Psychopharmacology, 231(14), 2825-2837 (2014-02-04)
In psychopharmacology, researchers have been interested in the hypnotic effects of terrestrial plant polyphenols and their synthetic derivatives. Phlorotannins, a marine plant polyphenol, could have potential as a source of novel hypnotic drugs. The effects of phlorotannins and major phlorotannin
Global Trade Item Number
| SKU | GTIN |
|---|---|
| F6300-100MG | 04061835370252 |
| F6300-25MG | 04061835370269 |