Key Documents

NO-711 hydrochloride

Name: NO-711 hydrochloride
Brand: SIGMA

≥98% (HPLC), GABA uptake inhibitor, powder

Synonym(s):

1-[2-[[(Diphenylmethylene)imino]oxy]ethyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride hydrochloride, NNC-711 hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₂N₂O₃ · HCl

CAS Number:

145645-62-1

Molecular Weight:

386.87

UNSPSC Code:

12352200

PubChem Substance ID:

24278817

NACRES:

NA.77

MDL number:

MFCD00153853

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated, protect from light

Pricing and availability is not currently available.

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Properties

Product Name

NO-711 hydrochloride, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated, protect from light

solubility

H₂O: 10 mg/mL at 60 °C

SMILES string

Cl[H].OC(=O)C1=CCCN(CCO\N=C(/c2ccccc2)c3ccccc3)C1

InChI

1S/C21H22N2O3.ClH/c24-21(25)19-12-7-13-23(16-19)14-15-26-22-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18;/h1-6,8-12H,7,13-16H2,(H,24,25);1H

InChI key

YZYRTEYMUTWJPL-UHFFFAOYSA-N

Gene Information

human ... GABBR1(2550), GABBR2(9568), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

Description

Application

NO-711 hydrochloride is suitable for use as γ-aminobutyric acid (GABA) transporter-1 (GAT-1) antagonists or GABA uptake inhibitor.

Biochem/physiol Actions

NO-711 is a potent and selective GABA uptake inhibitor that crosses the blood-brain barrier.

NO-711 is a potent and selective GABA uptake inhibitor.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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This Item	SML2570	M2824	SML0588
Sigma-Aldrich N142 NO-711 hydrochloride	Sigma-Aldrich SML2570 NSC 146109 hydrochloride	Sigma-Aldrich M2824 Meptazinol hydrochloride	Sigma-Aldrich SML0588 CP-94,253 dihydrochloride
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 100
storage condition desiccated, protect from light	storage condition desiccated	storage condition -	storage condition desiccated
Gene Information human ... GABBR1(2550), GABBR2(9568), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)	Gene Information -	Gene Information -	Gene Information -
solubility H₂O: 10 mg/mL at 60 °C	solubility DMSO: 2 mg/mL, clear	solubility H₂O: >10 mg/mL	solubility H₂O: 15 mg/mL, clear

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000528977

0000401777

0000380373

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Effects of GABAergic agents on anesthesia induced by halothane, isoflurane, and thiamylal in mice

Sugimura M, et al.

Pharmacology, Biochemistry, and Behavior, 72(1-2), 111-116 (2002)

Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor.

E B Nielsen et al.

European journal of pharmacology, 196(3), 257-266 (1991-04-24)

Tiagabine (NO-328) (R(-)-N-[4,4-bis(3-methylthien-2-yl)but-3-enyl]nipecotic acid, hydrochloride) is a new centrally acting GABA uptake inhibitor. The anticonvulsant activity of tiagabine was evaluated against seizures induced by methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), pentylenetetrazol, bicuculline, maximal electrostimulation (MES), or high intensity sound. The sedative actions of

Upregulation of the GABA-transporter GAT-1 in the spinal cord contributes to pain behaviour in experimental neuropathy

Daemen MARC, et al.

Neuroscience Letters, 444(1), 112-115 (2008)

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Global Trade Item Number

SKU	GTIN
N142-5MG	04061832092171
N142-25MG	04061832092164

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