A5835

γ-Aminobutyric acid

≥99%, suitable for ligand binding assays, BioXtra

• Synonym(s): 3-Carboxypropylamine, 4-Aminobutanoic acid, GABA, Piperidic acid, Piperidinic acid
• Linear Formula: NH₂(CH₂)₃COOH
• CAS Number: 56-12-2
• Molecular Weight: 103.12
• NACRES: NA.26
• PubChem Substance ID: 24891025
• UNSPSC Code: 12352106
• EC Number: 200-258-6
• MDL number: MFCD00008226
• Beilstein/REAXYS Number: 906818

Properties

• Product Name: γ-Aminobutyric acid, BioXtra, ≥99%
• product line: BioXtra
• Quality Segment: 200
• assay: ≥99%
• form: powder
• technique(s): ligand binding assay: suitable
• impurities: <0.0005% Phosphorus (P), <0.1% Insoluble matter
• ign. residue: <0.1%
• color: white
• mp: 195 °C (dec.) (lit.)
• solubility: H₂O: 0.5 M at 20 °C, clear, colorless
• anion traces: chloride (Cl^-): <0.04%, sulfate (SO₄^2-): <0.05%
• cation traces: Al: <5 mg/kg, Ca: <20 mg/kg, Cu: <5 mg/kg, Fe: <5 mg/kg, K: <50 mg/kg, Mg: <50 mg/kg, NH₄⁺: <500 mg/kg, Na: <70 mg/kg, Pb: <10 mg/kg, Zn: <5 mg/kg
• SMILES string: NCCCC(O)=O
• InChI: 1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
• InChI key: BTCSSZJGUNDROE-UHFFFAOYSA-N
• Gene Information: human ... SLC6A1(6529), SLC6A11(6538), SLC6A12(6539) ; rat ... Gabra1(29705), Gabra2(29706), Olr1750(294204), Slc6a1(79212), Slc6a12(50676)

Description

General description

γ-Aminobutyric acid (GABA) is a non-protein amino acid associated with the brain. Being synthesized in the nervous system, it is packed into synaptic vesicles. It is present naturally in green tea, soybean,[1] germinated rice, and in some fermented foods.[2]

Application

γ-Aminobutyric acid (GABA) has been used to treat dorsal root ganglion neurons for electrophysiological recordings studies to test its effect on neuropathic pain in rats.[3] It has also been used to test its protective effects in an ex vivo machine perfusion system of small-for-size grafts (SFSG) injury model.[4]

Biochem/physiol Actions

γ-Aminobutyric acid (GABA) is a mammalian inhibitory neurotransmitter with multiple functions.[1] It is crucial for the normal central nervous system (CNS) functioning.[2] A few documented functions of GABA include its protective role in toxin-induced damage. It also elicits anti-hypertensive, anti-diabetic, anti-microbial, antioxidant, anti-allergy, anti-inflammatory, and anti-cancer effects.[1] GABA might show beneficial effects on stress and sleep in humans.[2] γ-Aminobutyric acid (GABA) is used to study the biological and biochemical processes mediated via the GABA receptors, GABAA and GABAB.[1]

Major inhibitory neurotransmitter in brain; GABA_A and GABA_B receptor agonist; increases Cl⁻ conductance.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves