129876

Amiloride hydrochloride hydrate

≥98% (HPLC), angiogenesis inhibitor, solid

• Synonym(s): Amiloride, Hydrochloride, Acid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I
• Empirical Formula (Hill Notation): C₆H₈ClN₇O · xHCl
• CAS Number: 2016-88-8
• Molecular Weight: 229.63 (free base basis)
• MDL number: MFCD00058197
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic), protect from light

Properties

• Product Name: Amiloride, Hydrochloride, An inhibitor of angiogenesis.
• Quality Segment: 100
• description: Merck USA index - 14, 406
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• color: off-white to yellow
• solubility: water: 2.5 mg/mL, DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: Clc1nc(c(nc1N)N)C(=O)N\C(=N\[H])\N.Cl
• InChI: 1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H
• InChI key: ACHKKGDWZVCSNH-UHFFFAOYSA-N

Description

General description

An inhibitor of angiogenesis. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na⁺/H⁺ ATPase. Inhibits smooth muscle responses to contractile stimuli. Blocks palytoxin-induced conductance in skeletal muscle. Reduces the electrical potential across tubular epithelium. At higher concentrations, blocks the Na⁺/H⁺ exchange pathway.

An inhibitor of angiogenesis. Inhibits capillary morphogenesis completely and reversibly at approximately 130 µM. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na⁺ entry and Na⁺,K⁺-ATPase. Also acts as an inhibitor of urokinase-type plasminogen activator (uPA). Blocks smooth muscle responses to contractile stimuli and palytoxin-induced conductance in skeletal muscle. Reduces electrical potential across tubular epithelium. At higher concentrations, blocks the Na⁺/H⁺ exchange pathway.

Biochem/physiol Actions

Cell permeable: no

Primary Target
capillary morphogenesis

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 130 µM inhibiting capillary morphogenesis completely and reversibly

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Knoll, A., et al. 1999. Microvasc. Res.58, 1.
Swiercz, R., et al. 1999. Oncol. Rep.6, 523.
Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
Sugiyama, S., et al. 1988. J. Biol. Chem.263, 8215.
Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun.154, 101.
Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol.250, C175.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable