Skip to Content
MilliporeSigma

Key Documents

View All Documentation

Skip To

178281

p-APMSF hydrochloride

≥97% (HPLC), irreversible trypsin-like serine proteases inhibitor, solid

Synonym(s):

p-APMSF, Hydrochloride, p-Amidinophenylmethylsulfonylfluoride, HCl

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
5 mg
Check Cart for Availability
$190.00

About This Item

CAS Number:
74938-88-8
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00078902
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated

$190.00

Check Cart for Availability
​
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

p-APMSF, Hydrochloride, Alternative to DFP and PMSF.

Quality Segment

100

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

color

white

solubility

water: 25 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

F[S](=O)(=O)Cc1ccc(cc1)\C(=N\[H])\N.Cl

InChI

1S/C8H9FN2O2S.ClH/c9-14(12,13)5-6-1-3-7(4-2-6)8(10)11;/h1-4H,5H2,(H3,10,11);1H

InChI key

KHLLRHIUKOJXLL-UHFFFAOYSA-N

General description

Alternative to DFP and PMSF. An irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentration. Acts on C1r, C1s, Factor Xa, and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF.
An alternative to DFP and PMSF. Specific irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentrations. Acts on C1r, C1s, Factor Xa and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF. Stability is pH dependent: t½ = 20 min at pH 6.0; 6 min at pH 7.0; 1 millisecond at pH 8.0.

Biochem/physiol Actions

Cell permeable: no
Primary Target
trypsin-like serine proteases
Product does not compete with ATP.
Reversible: no

Preparation Note

Unstable in solution; reconstitute just prior to use.

Other Notes

Cole, T.C., et al. 1989. Biochim. Biophys. Acta 990, 254.
Laura, R., et al. 1980. Biochemistry19, 4859.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
203291573462454454
p-APMSF, Hydrochloride Alternative to DFP and PMSF.

Sigma-Aldrich

178281

p-APMSF, Hydrochloride

Bisindolylmaleimide I, Hydrochloride An enhanced water-soluble form of Bisindolylmaleimide I.

Sigma-Aldrich

203291

Bisindolylmaleimide I, Hydrochloride

Succinyl-Ala-Ala-Pro-Phe-p-nitroanilide Sensitive chromogenic substrate for human leukocyte cathepsin G that is not reactive with elastase.

Sigma-Aldrich

573462

Succinyl-Ala-Ala-Pro-Phe-p-nitroanilide

Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide Soluble, specific substrate for human leukocyte elastase.

Sigma-Aldrich

454454

Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide

form

solid

form

solid

form

solid

form

solid

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

water: 25 mg/mL

solubility

water: 10 mg/mL, DMSO: 20 mg/mL

solubility

DMSO: 100 mg/mL

solubility

ethanol: 1 mg/mL, DMF: 5 mg/mL, DMSO: 5 mg/mL

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

Reviews

No rating value

Active Filters