1466607

N-Nitrosomethylphenylamine (NMPA)

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): N-Methyl-N-nitrosoaniline, N-Methyl-N-nitrosobenzenamine, N-Methyl-N-phenylnitrosamine, NMPA
• Empirical Formula (Hill Notation): C₇H₈N₂O
• CAS Number: 614-00-6
• Molecular Weight: 136.15
• MDL number: MFCD00045675
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• agency: USP
• packaging: pkg of 1 mL
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: −20°C
• SMILES string: N(N=O)(C)c1ccccc1
• InChI: 1S/C7H8N2O/c1-9(8-10)7-5-3-2-4-6-7/h2-6H,1H3
• InChI key: MAXCWSIJKVASQC-UHFFFAOYSA-N

Description

General description

Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.

This product is provided as delivered and specified by the issuing Pharmacopoeia. For further information and support, including certificate/ product information sheets, please go to the website of the issuing Pharmacopoeia.

Application

N-Nitrosomethylphenylamine (NMPA) USP reference standard is intended for use only as specifically prescribed in the United States Pharmacopoeia.

It is also used to prepare standard, and sensitivity solutions to determine NMPA impurity in drug substances and drug products (valsartan, irbesartan, and losartan potassium etc) by chromatography according to general chapter 〈1469〉 of United States Pharmacopeia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  

Other Notes

Sales restrictions may apply.

Safety Information

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H350,H370
• pcodes: P202 - P210 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 1B - Flam. Liq. 2 - STOT SE 1
• target_organs: Eyes,Central nervous system
• Storage Class: 3 - Flammable liquids
• wgk: WGK 3
• flash_point_f: 49.5 °F
• flash_point_c: 9.7 °C