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T8904

Thiabendazole

≥99%, powder

Thiabendazole
1 of 1 reviewers received a sample product or took part in a promotion

Synonym(s):

2-(4-Thiazolyl)benzimidazole

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About This Item

Empirical Formula (Hill Notation):
C10H7N3S
CAS Number:
Molecular Weight:
201.25
UNSPSC Code:
51453501
NACRES:
NA.85
PubChem Substance ID:
EC Number:
205-725-8
Beilstein/REAXYS Number:
611403
MDL number:
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Quality Segment

assay

≥99%

form

powder

color

white to off-white

solubility

DMF: soluble 50 mg/mL

antibiotic activity spectrum

fungi, parasites

mode of action

enzyme | inhibits

SMILES string

c1ccc2[nH]c(nc2c1)-c3cscn3

InChI

1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)

InChI key

WJCNZQLZVWNLKY-UHFFFAOYSA-N

Gene Information

human ... CYP2C9(1559)

General description

Chemical structure: imidazole

Application

Thiabendazole (TBZ) is a broad-spectrum antihelminthic and is used to treat parasitic infections in humans. It is used as an agricultural fungicide and as a food preservative[1]. Thiabendazole has been used as a heavy metal chelating detoxification agent. It is used clinically to treat threadworm, cutaneous larva migrans, visceral larva migrans, and trichinosis[2].

Biochem/physiol Actions

Thiabendazole inhibits anaerobic respiration at the level of mitochondrial helminth-specific enzyme. It acts as a quinol-fumarate reductase (QFR) inhibitor in ,C. jejuni and H. pylori, blocking quinol oxidation to quinone. Thiabendazole suppresses egg and larval production and may inhibit the subsequent development of eggs and larvae which are passed in feces[2]. A proposed route of biotransformation of thiabendazole is the CYP1A2-catalyzed hydroxylation to 5-hydroxythiabendazole, which is metabolized to glucuronide and sulfate conjugates[1].

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids

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1 of 1

This Item
T5535165500045684
antibiotic activity spectrum

fungi, parasites

antibiotic activity spectrum

fungi

antibiotic activity spectrum

-

antibiotic activity spectrum

fungi

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

100

assay

≥99%

assay

-

assay

-

assay

-

form

powder

form

powder

form

-

form

-

solubility

DMF: soluble 50 mg/mL

solubility

-

solubility

-

solubility

-

Gene Information

human ... CYP2C9(1559)

Gene Information

human ... CYP2C9(1559)

Gene Information

-

Gene Information

-


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pictograms

Environment

signalword

Warning

hcodes

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves



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Global Trade Item Number

SKUGTIN
T8904-500G04061837379802
T8904-100G04061837379796

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

Reviews

Active Filters

  1. Melito di Porto Salvo (RC) - Italy
    • Reviews 2
    • Votes 2
    5 out of 5 stars.

    Quality

    Perfect quality & purity. Good price and fast shipping

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