T0576
Tau-441 human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder
Synonym(s):
Human Tau Protein, Tau Protein
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About This Item
Recommended Products
biological source
human
Quality Level
recombinant
expressed in E. coli
Assay
≥90% (SDS-PAGE)
form
lyophilized powder
mol wt
45.9 kDa
UniProt accession no.
application(s)
cell analysis
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... MAPT(4137)
General description
Tau-441 human, recombinant, is an isoform of Tau, variant 2N4R, having 4 microtubule binding repeats (R) and 2 amino terminal inserts (N). Tau is a family of neuronal microtubule-associated proteins. Tau, a phosphoprotein is considered as an important microtubule associated protein (MAP) of a mature neuron. The 2N4R tau consists of 441 amino acids (tau441) and is considered as the largest size human brain tau. In human brain, tau is present in six molecular isoforms.
The gene microtubule associated protein tau (MAPT) is localized on human chromosome 17q21.3. It is expressed in neurons, more specifically in axons.
Application
Human Tau-441 has been used to study the effects of tau on neuropathological changes in Alzheimer′s disease.
Tau-441 human has been used to study its effects on mitochondrial transport velocities found in glial cells.
Biochem/physiol Actions
Microtubule associated protein tau (MAPT) plays an important role in the assembly and maintenance of the microtubule structure. Loss of expression of MAPT results in developmental delay and learning disability. The protein has been associated with pathology of Alzheimer′s disease (AD).
Tau promotes assembly and stabilizes neuronal microtubules under normal physiological conditions.
Isoform of Tau, variant 2N4R, having 4 microtubule binding repeats (R) and 2 amino terminal inserts (N)
Reconstitution
Lyophilized from MES, pH 6.8, containing NaCl and EGTA. When reconstituted in water to a protein concentration of 1 mg/mL, the resulting buffer will have ~50 mM MES, pH 6.8, 100 mM NaCl, and 0.5 mM EGTA.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Seed-competent HMW tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients
Shuko Takeda
Annals of Neurology (2016)
Microdeletion encompassing MAPT at chromosome 17q21. 3 is associated with developmental delay and learning disability
Shaw-Smith, Charles, et al
Nature Genetics, 38 (2006)
Preliminary study of effect of exogenous tau-441 on mitochondrial transport in glia.
Morgan MX
wheaton journal of neurobiology research (2017)
The H1c haplotype at the MAPT locus is associated with Alzheimer's disease
A. J. Myers
Human Molecular Genetics, 14 (2005)
Tau in Alzheimer Disease and Related Tauopathies
Iqbal K, et al.
Current Alzheimer Research, 7(8), 656-656 (2010)
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