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Proteoglycan from bovine nasal septum

Name: Proteoglycan from bovine nasal septum
Brand: SIGMA

chromatographically purified

Synonym(s):

Bovine Proteoglycan, Nasal Proteoglycan

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.61

MDL number:

MFCD00212609

Form:

powder

Biological source:

bovine nasal septum

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Properties

biological source

bovine nasal septum

Quality Segment

100

form

powder

technique(s)

cell culture | stem cell: suitable

UniProt accession no.

F1MDS0

storage temp.

−20°C

Gene Information

bovine ... PRG4(280867)

Description

General description

Proteoglycans are made up of a core protein to which glycosaminoglycan chains are linked covalently. They are present in many organs, and tissues and found abundantly in the vertebrate cartilage matrix. Proteoglycans are located in the extracellular and pericellular matrix of many cells.

Application

Proteoglycan from bovine nasal septum contains 86% chondroitin sulfate and so has been used to study the effects of chondroitin sulfate proteoglycan in vitro. It has been shown to promote survival of neural stem cells in culture. [1]

Proteoglycan from bovine nasal septum has been used in the induction of arthritis in mice.

Biochem/physiol Actions

Proteoglycans are involved in tissue organization and promote cell growth and specialized tissue maturation. They act as biological filters and regulate collagen fibrillogenesis, skin tensile strength, and neurite growth. Proteoglycans are also involved in modulating growth-factor activities, affecting tumor cell growth and invasion, and promoting corneal transparency.

Preparation Note

Chromatographically purified using 7M urea on DEAE-cellulose by modified procedure by Antonopoulos.

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This Item	D8428	F3004	A1470
Sigma-Aldrich P5864 Proteoglycan from bovine nasal septum	Sigma-Aldrich D8428 Decorin from bovine articular cartilage	Sigma-Aldrich F3004 Fetuin from fetal bovine serum	Sigma-Aldrich A1470 Bovine Serum Albumin
biological source bovine nasal septum	biological source bovine articular cartilage	biological source bovine serum (fetal)	biological source bovine
technique(s) cell culture \| stem cell: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) HPLC: suitable, MALDI-MS: suitable	technique(s) cell culture \| mammalian: suitable
form powder	form salt-free, lyophilized powder	form lyophilized powder	form lyophilized powder
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C
UniProt accession no. F1MDS0	UniProt accession no. P21793	UniProt accession no. Q58D62	UniProt accession no. P02769
Gene Information bovine ... PRG4(280867)	Gene Information cow ... DCN(280760)	Gene Information bovine ... FETUB(504615)	Gene Information bovine ... ALB(280717)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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