This product meets 4X the minimum USP specifications. According to the USP monograph for Pancreatin, the 1X minimum specification is 25 USP units amylase, 2 USP units lipase, and 25 USP units protease per milligram. The calculated protease activity for the 4X preparation then, would be at least 100 units per milligram. This is a calculated value based on the USP monograph and are not reported separately on the Certificate of Analysis.
P1750
Pancreatin from porcine pancreas
4 × USP specifications
Synonym(s):
Pancreatin from hog pancreas
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About This Item
Specific activity:
4 × USP specifications
Pricing and availability is not currently available.
agency
USP (specifications)
Quality Level
form
powder
specific activity
4 × USP specifications
contains
lactose or sucrose as extender (The sucrose used might contain up to 3.25% starch.)
storage temp.
−20°C
Application
Pancreatin from porcine pancreas has been used:
- for a study to assess the treatment of steatorrhea by lipase supplementation therapy[1]
- for a study to investigate treatment options for pancreatic diabetes in patients experiencing the decompensated stage of chronic pancreatitis[2]
- to safely and effectively remove formalin-fixed tissues from arterial grafts without causing structural damage and loss in fiber integrity [3]
- to assess cleavage by digestive enzymes.
- for in vitro digestibility analysis and to test the sensitivities of cellulolytic bacteria inhibitors.[4]
- along with amyloglucosidase for the in vitro digestion of starch in food samples.[5]
Biochem/physiol Actions
Pancreatin contains enzymatic components including trypsin, amylase and lipase, ribonuclease, and protease, produced by the exocrine cells of the porcine pancreas. This combination of enzymes allows it to hydrolyze proteins, starch and fats. Pancreatin will convert not less than 25 times its weight of potato starch into soluble carbohydrates in 5 minutes in water at 40°C, will digest not less than 25 times its weight of casein in 60 minutes at pH 7.5 at 40°C and will release not less than microequivalents of acid per min per mg pancreatin from olive oil at pH 9.0 at 37°C.
1 of 1
This Item | |||
|---|---|---|---|
| specific activity 4 × USP specifications | specific activity 8 × USP specifications | specific activity ≥3 × USP specifications | specific activity - |
| form powder | form powder | form powder | form solid |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 500 |
| agency USP (specifications) | agency - | agency USP (specifications) | agency Ph. Eur., USP |
| contains lactose or sucrose as extender (The sucrose used might contain up to 3.25% starch.) | contains lactose as extender | contains - | contains - |
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signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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David C Whitcomb et al.
Digestive diseases and sciences, 52(1), 1-17 (2007-01-06)
A primary function of the pancreas is to produce digestive enzymes that are delivered to the small intestine for the hydrolysis of complex nutrients. Much of our understanding of digestive enzymes comes from studies in animals. New technologies and the
Peter Layer et al.
Pancreas, 26(1), 1-7 (2002-12-25)
Treatment of steatorrhea by lipase supplementation therapy has become more successful in the last decade due to better understanding of the physiology and pathophysiology of the digestive process. Porcine lipase has been the therapeutic standard for several decades and will
Asavela Ngalavu et al.
Animals : an open access journal from MDPI, 10(4) (2020-04-17)
Feed fiber composition is usually considered as one of the factors that have an impact on digestive tract microbiota composition. The investigations on the level of fermentation and in-vitro digestibility of different fibers are not well understood. The aim of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P1750-25G | 04061835558247 |
| P1750-100G | 04061835546299 |
| P1750-500G | 04061835558254 |
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units of pancreatin cas number 8049-47-6
1 answer-
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What is the trypsin activity of this P1750 product ?
1 answer-
This product is not specifically tested for trypsin activity. The material meets USP requirements. This monograph includes testing for protease, amylase, and lipase.
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What is the solubility of p1750 pancreatin in water?
1 answer-
This product is soluble at 7 mg/mL in water and may yield a hazy solution.
Helpful?
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As per USP: Pancreatin contains, in each mg, not less than 25 USP Units of protease activity. I assume that product P1750 contains minimum 100 USP units of protease activity in each mg. What is the maximum USP units of protease activity in P1750 ?
1 answer-
Yes, this is correct. To meet the USP specifications, the protease activity will be less than 100 USP Units/mg.
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