P0037

PP242 hydrate

≥98% (HPLC), powder

• Synonym(s): 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol
• Empirical Formula (Hill Notation): C₁₆H₁₆N₆O · xH₂O
• CAS Number: 1173019-76-5
• Molecular Weight: 308.34 (anhydrous basis)
• MDL number: MFCD12828866
• UNSPSC Code: 12352200
• PubChem Substance ID: 329819988
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: off-white
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c4c(N)ncnc14
• InChI: 1S/C16H16N6O.H2O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12;/h3-8,20,23H,1-2H3,(H2,17,18,19);1H2
• InChI key: FMDOLJSFPXFBIL-UHFFFAOYSA-N

Description

Application

PP242 hydrate has been used:

• as a mammalian target of rapamycin (mTOR) inhibitor to study its effects on rat fibroblast mTOR complex 1 and 2 (mTORC1 & 2) signaling [1]
• as an mTOR inhibitor to treat mouse embryonic fibroblasts (MEF) and cumulus cells (CCs) to study its effects on reactivation of embryonic nucleoli and ribosome biogenesis [2]
• as a target of rapamycin (TOR) kinase inhibitor for the treatment of Arabidopsis to study its effects against Fusarium graminearum infection [3]

Biochem/physiol Actions

PP242 is a potent and selective mTOR inhibitor.

PP242 is a potent and selective mTOR inhibitor. PP242 is a first selective inhibitor that targets ATP domain of mTOR.

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable