Unfortunately, we do not test any of our products such as M0418 for specific applications. We sell products in small scale for laboratory use and application. The information is based on that Melanin as a small molecule used in Cell culture application. We do not have specific publications or protocols to share.
M0418
Melanin
Synthetic, BioReagent, suitable for cell culture
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About This Item
Pricing and availability is not currently available.
biological source
synthetic
product line
BioReagent
assay
≥85% (TLC)
form
powder
technique(s)
cell culture | mammalian: suitable
solubility
1 N NH4OH: 20 mg/mL
storage temp.
−20°C
SMILES string
[nH]1c2c3c(c4c5c([nH]c4)c([c]([c](c5c3c1)=O)=O)C)[c]([c](c2C)=O)=O
InChI
1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3
InChI key
XUMBMVFBXHLACL-UHFFFAOYSA-N
General description
Melanin is a distinctive class of pigment found in animals, plants, bacteria, and fungi. It is an amorphous polymer formed by the polymerization of phenolic and indolic compounds.
Application
Melanin has been used:
- to incubate normal human keratinocytes for Masson-Fontana staining
- as a standard in the determination of melanin content in normal human epidermal melanocytes and immortalized human keratinocytes
- as an absorber to mimic human skin or melanocytic nevi and melanoma
Biochem/physiol Actions
Melanin plays a role in camouflage and energy harvesting. It also helps in protection against ionizing UV radiations, protection against biotic factors such as host defense against pathogens, and abiotic factors like heat, cold and osmotic stress. Melanin acts as a potent cation chelator and is a component of several photoprotective creams as it facilitates free radical scavenging activity. Melanin may be useful as a photo protectant in cell culture.
Preparation Note
Prepared by oxidation of tyrosine with hydrogen peroxide.
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This Item | |||
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| technique(s) cell culture | mammalian: suitable | technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - | technique(s) - |
| solubility 1 N NH4OH: 20 mg/mL | solubility - | solubility - | solubility 3.2 g/L |
| form powder | form - | form powder | form powder |
| storage temp. −20°C | storage temp. 2-30°C | storage temp. −20°C | storage temp. no temp limit |
| assay ≥85% (TLC) | assay - | assay - | assay - |
| product line BioReagent | product line - | product line - | product line - |
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| M0418-1G | 04061835568796 |
| M0418-100MG | 04061833993132 |
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Is there any pretreatment other than sonication that should be done before adding to cells? Also, please let me know if there are any precedents for such processing.
1 answer-
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I wonder if you can let me know what type of melanin pigment this reagent has. Is it pheo-, eu- or mixed melanin? What is the level of polymerization? Thank you!
1 answer-
This product is synthetic melanin, per Med. Res. Reviews 8 (1988) pp. 525-556, synthetic melanins are "eumelanin type pigments". Unfortunately, no additional information on the level of polymerization is available.
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