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L-745,870 hydrochloride

Name: L-745,870 hydrochloride
Brand: SIGMA

Synonym(s):

3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₉ClN₄ · HCl

CAS Number:

1173023-36-3

Molecular Weight:

363.28

NACRES:

NA.77

PubChem Substance ID:

24277918

UNSPSC Code:

12352200

MDL number:

MFCD01529971

Form:

solid

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Properties

form

solid

Quality Segment

100

color

white

solubility

H₂O: 0.2 mg/mL, ethanol: 1.4 mg/mL, 0.1 M HCl: 5.5 mg/mL

SMILES string

Cl.Clc1ccc(cc1)N2CCN(CC2)Cc3c[nH]c4ncccc34

InChI

1S/C18H19ClN4.ClH/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18;/h1-7,12H,8-11,13H2,(H,20,21);1H

InChI key

GFFJYISJZJIKAF-UHFFFAOYSA-N

Gene Information

human ... DRD4(1815)

Description

Biochem/physiol Actions

Selective D₄ dopamine receptor antagonist.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Manufactured and sold under license from Merck & Co., Inc., Kenilworth, NJ, U.S. for use solely for preclinical researchy purposes (i.e., not for the administration to or other use in humans).

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This Item	U101	G119	A9736
Sigma-Aldrich L131 L-745,870 hydrochloride	Sigma-Aldrich U101 5-Methylurapidil	Sigma-Aldrich G119 GYKI 52466 hydrochloride	Sigma-Aldrich A9736 A-438079 hydrochloride hydrate
form solid	form solid	form solid	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility H₂O: 0.2 mg/mL, 0.1 M HCl: 5.5 mg/mL, ethanol: 1.4 mg/mL	solubility H₂O: 0.4 mg/mL, 0.1 M HCl: 3.8 mg/mL	solubility DMSO: 0.39 mg/mL, ethanol: 0.4 mg/mL, 0.1 M HCl: 0.68 mg/mL, methanol: 1 mg/mL, H₂O: >10 mg/mL	solubility DMSO: 20 mg/mL, clear
color white	color white	color yellow	color white to beige
Gene Information human ... DRD4(1815)	Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)	Gene Information human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)	Gene Information -

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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