H6503

L-Homocysteine thiolactone hydrochloride

≥98% (TLC)

• Synonym(s): L-2-Amino-4-mercaptobutyric acid 1,4-thiolactone hydrochloride
• Empirical Formula (Hill Notation): C₄H₇NOS · HCl
• CAS Number: 31828-68-9
• Molecular Weight: 153.63
• NACRES: NA.26
• PubChem Substance ID: 24895745
• eCl@ss: 32160406
• UNSPSC Code: 12352209
• EC Number: 250-824-1
• MDL number: MFCD00065494
• Beilstein/REAXYS Number: 3911455

Properties

• Product Name: L-Homocysteine thiolactone hydrochloride, ≥98% (TLC)
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• color: white
• mp: 185 °C
• application(s): detection; peptide synthesis
• SMILES string: Cl[H].N[C@H]1CCSC1=O
• InChI: 1S/C4H7NOS.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H/t3-;/m0./s1
• InChI key: ZSEGSUBKDDEALH-DFWYDOINSA-N

Description

Application

• Effects of DL-homocysteine thiolactone on cardiac contractility, coronary flow, and oxidative stress markers in the isolated rat heart: This investigation demonstrates the effects of DL-homocysteine thiolactone on heart function, offering insights into its use in cardiovascular research and potential therapeutic applications (Zivkovic et al., 2013).


• Homocysteine is a novel risk factor for suboptimal response of blood platelets to acetylsalicylic acid in coronary artery disease: The study explores how L-homocysteine thiolactone could affect platelet responses in therapy for coronary artery diseases, pointing to its importance in cardiovascular therapeutics (Karolczak et al., 2013).

Biochem/physiol Actions

L-Homocysteine thiolactone, an amine reactive agent, is used to study post-translational modification of proteins, especially at lysine residues.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)