G8903
Ghrelin rat
lyophilized powder
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About This Item
Pricing and availability is not currently available.
form
lyophilized powder
Quality Segment
color
white
solubility
1% acetic acid: 1 mg/mL, water: 1 mg/mL
UniProt accession no.
storage temp.
−20°C
Gene Information
rat ... Ghrl(59301)
General description
Ghrelin is a gut-brain orexigenic peptide that functions in hunger signaling. This peptide is prominently synthesized by stomach and transported to brain. However, a specific subset of hypothalamic neurons also produces this peptide.[1] It is expressed in gastrointestinal tract, hypothalamic arcuate nucleus, pituitary, kidney, liver, heart, lung and adipose tissue This peptide is composed of 28 amino acids, and its Ser3 residue is N-octanoylated.[2]
Application
Ghrelin rat has been used for intraperitoneal injections, and microinjections in rats to study its effects on celiac disease,[3] and passive avoidance learning (PAV) and spatial learning, respectively.[4][5] It has also been used for intracerebroventricular injection in rats to study its influence on penicillin-induced epileptiform activity in rat.[6]
Biochem/physiol Actions
Endogenous ligand to the orphan growth-hormone secretagogue receptor that stimulates the release of growth hormone from the pituitary.
Ghrelin acts as a ligand for G-protein coupled receptor, GHS-R1A (growth hormone secretagogue receptor), and controls energy utilization and feeding. This peptide is involved in enhancing the value of rewarding foods, drugs and alcohol.[1] In rats with diabetes, the expression of ghrelin increased as a result of cachexia.[2] In rats with ovariectomy, the expression of this peptide decreased in the endometrium.[7] This peptide controls cognitive functions and has neuroprotective roles in neurodegenerative disorders. In cultured cortical neuronal networks, ghrelin increases the rate of synapse formation and activity development.[8]
Physical form
Lyophilized from 0.1% aqueous TFA
Other Notes
Lyophilized from 0.1% TFA in H2O
1 of 1
This Item | |||
|---|---|---|---|
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. - |
| Gene Information rat ... Ghrl(59301) | Gene Information rat ... NGF(4803) | Gene Information rat ... ALB(24186) | Gene Information human ... GHRL(51738) |
| solubility 1% acetic acid: 1 mg/mL, water: 1 mg/mL | solubility water: soluble 0.1 g/L at 20 °C | solubility - | solubility deionized water: 1 mg/mL |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| G8903-.1MG | 04061833649985 |