F3639
4-Fluoro-7-sulfamoylbenzofurazan
Synonym(s):
4-(Aminosulfonyl)-7-fluorobenzofurazane, 7-Fluoro-2,1,3-benzoxadiazole-4-sulfonamide, 7-Fluorobenzofurazan-4-sulfonamide, ABD-F
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About This Item
Empirical Formula (Hill Notation):
C6H4FN3O3S
CAS Number:
Molecular Weight:
217.18
UNSPSC Code:
12352108
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5035147
Pricing and availability is not currently available.
storage temp.
−20°C
Quality Segment
SMILES string
NS(=O)(=O)c1ccc(F)c2nonc12
InChI
1S/C6H4FN3O3S/c7-3-1-2-4(14(8,11)12)6-5(3)9-13-10-6/h1-2H,(H2,8,11,12)
InChI key
XROXHZMRDABMHS-UHFFFAOYSA-N
General description
4-Fluoro-7-sulfamoylbenzofurazan is a fluorescent reagent, which directly links to the sulfur atom of thiols without a flexible alkyl chain. It is used to detect low molecular thiols using high performance liquid chromatography.[1]
Application
Reagent for fluorimetric assay of thiols.
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| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. room temp | storage temp. −20°C |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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J Nishihira et al.
Biochemical and biophysical research communications, 188(1), 424-432 (1992-10-15)
Glutathione S-transferase P (GST-P) lost the enzymatic activity by 7-fluoro-4-sulfamoyl-2, 1, 3-benzodiazole (ABD-F), a thiol-group chemical modifier, but did not by methylmethanethiol-sulfonate. Both ABD-F and methylmethanethiolsulfonate reacted with Cys47 and Cys101. These two cysteine residues were site-directedly mutated with serine
I J Kim et al.
Journal of chromatography. A, 877(1-2), 217-223 (2000-06-14)
Homocysteine was derivatized with 4-aminosulfonyl-7-fluoro-2,1,3-benzoxadiazole (ABD-F) to form an inclusion complex with cyclodextrin and to facilitate UV detection. ABD-homocysteine showed interaction with beta- and gamma-cyclodextrin in capillary electrophoresis at pH 2.25 as indicated by the decreased migration time. However, chiral
S L Lauren et al.
Journal of chromatography. A, 798(1-2), 47-54 (1998-05-02)
The complete removal of the fluorescent cysteine derivative 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole (ABD-F) from an intact protein has not been demonstrated even after extended treatment with a reducing agent. It has been suggested that this may be due to incomplete denaturation under the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| F3639-50MG | 04061832534671 |
| F3639-10MG | 04061833284773 |