F2929

6-Fluoromevalonate

≥90% (GC), Mevalonate-pyrophosphate decarboxylase inhibitor, viscous liquid

• Synonym(s): Tetrahydro-4-fluoromethyl-4-hydroxy-2H-pyran-2-one, ZR 3516
• Empirical Formula (Hill Notation): C₆H₉FO₃
• CAS Number: 2822-77-7
• Molecular Weight: 148.13
• UNSPSC Code: 51111800
• PubChem Substance ID: 24724480
• NACRES: NA.77
• MDL number: MFCD08276919
• Assay: ≥90% (GC)
• Form: viscous liquid
• Quality level: 100

Properties

• Product Name: 6-Fluoromevalonate, ≥90% (GC), viscous liquid
• Quality Level: 100
• assay: ≥90% (GC)
• form: viscous liquid
• color: yellow tint
• solubility: DMSO: ≥3 mg/mL
• storage temp.: 2-8°C
• SMILES string: OC1(CF)CCOC(=O)C1
• InChI: 1S/C6H9FO3/c7-4-6(9)1-2-10-5(8)3-6/h9H,1-4H2
• InChI key: DPPMVKMESJJAJZ-UHFFFAOYSA-N

Description

Application

6-Fluoromevalonate has been used as a mevalonate pyrophosphate decarboxylase inhibitor:

• to study the effect of mevalonate pathway inhibition on patient-derived brain tumor-initiating cells (BTICs) growth and self-renewal
• to study its effect on induction of trained immunity by β-glucan in monocytes
• to determine the effect of the mevalonate pathway (MVP) on ADP-ribosylation factor 6 (ARF6) activation

Biochem/physiol Actions

Mevalonate-pyrophosphate decarboxylase inhibitor

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)