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FPL 64176

Name: FPL 64176
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxlic acid methyl ester

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₁NO₃

CAS Number:

120934-96-5

Molecular Weight:

347.41

NACRES:

NA.77

PubChem Substance ID:

24277836

UNSPSC Code:

12352200

MDL number:

MFCD00274043

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

Storage condition:

desiccated, protect from light

Pricing and availability is not currently available.

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Properties

Quality Level

200

assay

≥98% (HPLC)

form

powder

storage condition

desiccated, protect from light

color

white to beige

solubility

DMSO: >20 mg/mL (Solutions should be freshly prepared.), H₂O: insoluble

storage temp.

2-8°C

SMILES string

COC(=O)c1c(C)[nH]c(C)c1C(=O)c2ccccc2Cc3ccccc3

InChI

1S/C22H21NO3/c1-14-19(20(15(2)23-14)22(25)26-3)21(24)18-12-8-7-11-17(18)13-16-9-5-4-6-10-16/h4-12,23H,13H2,1-3H3

InChI key

MDMWHKZANMNXTF-UHFFFAOYSA-N

Gene Information

rat ... Cacnb3(25297)

Description

Biochem/physiol Actions

Potent Ca²⁺ channel (L-type) activator.

Legal Information

Manufactured and sold with permission from Astra Charnwood.

Disclaimer

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This Item	SML0002	SML1937	SML0084
Sigma-Aldrich F131 FPL 64176	Sigma-Aldrich SML0002 C646	Sigma-Aldrich SML1937 SN-6	Sigma-Aldrich SML0084 IM-12
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: >20 mg/mL (Solutions should be freshly prepared.), H₂O: insoluble	solubility DMSO: >25 mg/mL	solubility DMSO: 2 mg/mL, clear	solubility DMSO: ≥9 mg/mL
storage condition desiccated, protect from light	storage condition desiccated	storage condition desiccated	storage condition desiccated

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Ionic currents in intimal cultured synoviocytes from the rabbit.

R J Large et al.

American journal of physiology. Cell physiology, 299(5), C1180-C1194 (2010-08-20)

Hyaluronan, a joint lubricant and regulator of synovial fluid content, is secreted by fibroblast-like synoviocytes lining the joint cavity, and secretion is greatly stimulated by Ca(2+)-dependent protein kinase C. This study aimed to define synoviocyte membrane currents and channels that

Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells.

Jeffrey J Ross et al.

The Journal of clinical investigation, 116(12), 3139-3149 (2006-11-14)

Smooth muscle formation and function are critical in development and postnatal life. Hence, studies aimed at better understanding SMC differentiation are of great importance. Here, we report that multipotent adult progenitor cells (MAPCs) isolated from rat, murine, porcine, and human

Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations.

W Zheng et al.

Molecular pharmacology, 40(5), 734-741 (1991-11-01)

The pharmacological, radioligand binding, and electrophysiological properties of FPL 64176, a new nondihydropyridine Ca2+ channel activator, were studied in rat tail artery, cardiac membranes, and A7r5 smooth muscle cells. FPL 64176 induced a contractile response, with an EC50 value of

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Global Trade Item Number

SKU	GTIN
F131-25MG	04061832961613
F131-100MG	04061832961606

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