Key Documents

Chloro-APB hydrobromide

Name: Chloro-APB hydrobromide
Brand: SIGMA

solid

Synonym(s):

(±)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, (±)-SKF-82958 hydrobromide, 6-Chloro-N-allyl-SKF-38393 hydrobromide

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₀ClNO₂ · HBr

CAS Number:

80751-65-1

Molecular Weight:

410.73

NACRES:

NA.77

PubChem Substance ID:

24277890

UNSPSC Code:

12352200

MDL number:

MFCD00069235

Form:

solid

Quality level:

100

Pricing and availability is not currently available.

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Properties

form

solid

Quality Level

100

color

tan

solubility

H₂O: 3.7 mg/mL, aqueous base: unstable, ethanol: soluble

storage temp.

2-8°C

SMILES string

Br.Oc1cc2C(CN(CCc2c(Cl)c1O)CC=C)c3ccccc3

InChI

1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H

InChI key

WLXGFAVTAAQOFH-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812)

Description

Application

Chloro-APB hydrobromide has been used to pharmacologically stimulate D1 dopamine receptors and study its influence on locomotor response in fat mass and obesity-associated protein (FTO) deficient dopamine D1 receptor-expressing medium spiny neurons (D1 MSNs) of mice.[1]

Biochem/physiol Actions

Chloro-APB hydrobromide, also known as SKF 82958, is a D1 dopamine receptor agonist.[1] D1 receptor agonists prevent and reverse fentanyl-induced respiratory depression, without impairing opioid analgesia, in cats.[2]

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This Item	S143	D054	D047
Sigma-Aldrich C130 Chloro-APB hydrobromide	Sigma-Aldrich S143 (±)-6-Chloro-PB hydrobromide	Sigma-Aldrich D054 R(+)-SCH-23390 hydrochloride	Sigma-Aldrich D047 (±)-SKF-38393 hydrochloride
form solid	form solid	form solid	form crystalline
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. -	storage temp. -	storage temp. -
solubility H₂O: 3.7 mg/mL, ethanol: soluble, aqueous base: unstable	solubility H₂O: 1.7 mg/mL, DMSO: >10 mg/mL, ethanol: 6.3 mg/mL	solubility H₂O: >5 mg/mL	solubility H₂O: >5 mg/mL, aqueous base: soluble (unstable)
color tan	color white to light tan	color white	color white
Gene Information human ... DRD1(1812)	Gene Information human ... DRD1(1812)	Gene Information human ... DRD1(1812)	Gene Information human ... DRD1(1812)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000461217

0000270648

075M4609V

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Reward-potentiating effects of D-1 dopamine receptor agonist and AMPAR GluR1 antagonist in nucleus accumbens shell and their modulation by food restriction.

Kenneth D Carr et al.

Psychopharmacology, 202(4), 731-743 (2008-10-09)

Previous studies have suggested that chronic food restriction (FR) increases sensitivity of a neural substrate for drug reward. The neuroanatomical site(s) of key neuroadaptations may include nucleus accumbens (NAc) where changes in D-1 dopamine (DA) receptor-mediated cell signaling and gene

Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats.

Elena H Chartoff et al.

Psychopharmacology, 204(2), 227-239 (2009-01-17)

Chronic opiate administration induces neuroadaptations within the nucleus accumbens (NAc) and ventral tegmental area (VTA) that can contribute to dependence. We have shown that morphine dependence shifts the behavioral consequences of D1 dopamine (DA) receptor signaling: systemic administration of a

D1-dopamine receptor agonists prevent and reverse opiate depression of breathing but not antinociception in the cat.

Peter M Lalley

American journal of physiology. Regulatory, integrative and comparative physiology, 289(1), R45-R51 (2005-02-12)

Opioids depress respiration and decrease chest wall compliance. A previous study in this laboratory showed that dopamine-D(1) receptor (D(1)R) agonists restored phrenic nerve activity after arrest by fentanyl in immobilized, mechanically ventilated cats. The reinstated phrenic nerve rhythm was slower

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Global Trade Item Number

SKU	GTIN
C130-5MG	04061832081397
C130-100MG	04061833467312
C130-25MG	04061833467329

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Chloro-APB hydrobromide

solid

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About This Item

form

Quality Level

color

solubility

storage temp.

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InChI key

Gene Information

Application

Biochem/physiol Actions

Disclaimer

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Storage Class

wgk

flash_point_f

flash_point_c

ppe

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