B4397

Bradykinin Fragment 1-8 acetate salt hydrate

≥97% (HPLC)

• Synonym(s): [des-Arg⁹]-Bradykinin acetate salt hydrate
• Empirical Formula (Hill Notation): C₄₄H₆₁N₁₁O₁₀ · xC₂H₄O₂ · yH₂O
• Molecular Weight: 904.02 (anhydrous free base basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 24891773
• MDL number: MFCD00236892
• Assay: ≥97% (HPLC)
• Form: powder

Properties

• assay: ≥97% (HPLC)
• form: powder
• UniProt accession no.: P01042
• storage temp.: −20°C
• SMILES string: NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(=O)NC(CO)C(=O)N4CCCC4C(=O)NC(Cc5ccccc5)C(O)=O
• InChI: 1S/C44H61N11O10/c45-29(15-7-19-48-44(46)47)40(61)55-22-10-18-35(55)42(63)54-21-8-16-33(54)38(59)49-25-36(57)50-30(23-27-11-3-1-4-12-27)37(58)52-32(26-56)41(62)53-20-9-17-34(53)39(60)51-31(43(64)65)24-28-13-5-2-6-14-28/h1-6,11-14,29-35,56H,7-10,15-26,45H2,(H,49,59)(H,50,57)(H,51,60)(H,52,58)(H,64,65)(H4,46,47,48)
• InChI key: VCEHWDBVPZFHAG-UHFFFAOYSA-N
• Gene Information: human ... KNG1 (includes EG:3827)

Description

General description

Bradykinin Fragment 1-8, also known as des-Arg9-bradykinin, is produced by the cleavage of bradykinin at 8-9 position by carboxypeptidase N.[1]

Application

Bradykinin Fragment 1-8 acetate salt hydrate has been used as a Bradykinin 1 receptor (B1R) agonist to investigate the expression and the role of B1R, in mediating neuronal injury under the chemical neurotoxicity paradigm in PC12 cell lines.[2] It has also been used as an analyte in nanostructure-initiator mass spectrometry and matrix-assisted laser desorption/ionization (MALDI).[3]

Biochem/physiol Actions

Bradykinin Fragment 1-8 is a selective B1 bradykinin receptor agonist.[4] It promotes the release of nitric oxide, prostacyclin, endothelium-derived hyperpolarizing factor in the endothelium. des-Arg9-bradykinin also promotes vasodilatation and increases blood flow in the peripheral circulation.[5]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)